Op voordracht van prof.dr. Roderich Suessmuth van de Technische Universiteit van Berlijn ontving prof.dr. Herman Overkleeft de Friedrich Wilhelm Bessel Research Award. Van Overkleeft is in Leiden verbonden aan het Leiden Institute of Chemistry, LIC/Bio-organic Synthesis.

Webinar with Q&A

The LIACS Media Lab has received a research grant from the worldwide leading graphics hardware company NVIDIA. The grant exists of newly developed hardware utilizing thousands of processors. LIACS researchers will use it to investigate deep learning in understanding imagery from sources such as MRI…

Researchers from the Department of Economics - Kees Goudswaard, Koen Caminada, Marike Knoef, Pierre Koning and Olaf van Vliet - have been awarded a grant of one million euros by Instituut Gak to investigate self-sufficiency and social protection.

President Joko Widodo van Indonesië heeft besloten dat zijn land een nieuwe hoofdstad krijgt. Maar wat betekent zo’n grote beslissing eigenlijk voor het land? David Henley, hoogleraar Moderne Indonesië Studies, geeft op Radio 1 bij Nieuws en Co uitleg over deze belangrijke keuze in de geschiedenis van…

De Environmental Sciences Research Prize 2012 is uitgereikt aan CML onderzoeker David Font Vivanco door de Environmental Scientists Association van Catalonië.

Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?

Een artikel dat Holger Hoos, hoogleraar Machine Learning aan het Leiden Institute of Advanced Computer Science (LIACS), schreef met zijn voormalige masterstudent Jasper van Engelen is door SpringerNature geselecteerd als een van de zes Research Highlights in Computer Science van 2020. Nadat hij in januari…

Sinds 2009 behaalden 95 kandidaten hun doctoraat in Creative en Performing Arts. Op deze pagina een overzicht van ACPA's alumni.

In de academische wereld moet meer aandacht komen voor data- en softwaremanagement. Dat zegt Jaap van den Herik (directeur van het Leiden Centre of Data Science) in een interview met E-Data & Research.

Vijf Leidse bachelorstudenten strijden op de Student Research Conference met hun onderzoek mee om de kwalificatie 'Het beste bacheloronderzoek van Nederland en België'. Jelmer Wagenaar (Natuurkunde) zoekt naar nog kleinere geheugenopslag. Samen met de andere kandidaten presenteert hij op 24 november…

Hans de Bruijn studeerde cum laude af en schreef zijn onderzoeksplan tijdens een speciale masteropleiding voor getalenteerde chemiestudenten van de Holland Research School (HRSMC). Zijn voorstel werd gehonoreerd en De Bruijn start later dit jaar zijn door NWO en HRSCM gefinancierde promotietraject.

How and to what extent the historic house (re-)constructs identity through image-making in China.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.

Promotores: J. Zaanen, A. Parnachev

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Op 12 december verdedigde Anke van der Hoeven het proefschrift 'Met de vlam in de pijp door Europa - De arbeidssituatie van internationale vrachtwagenchauffeurs: constructies en percepties'. Het promotieonderzoek is begeleid door Joanne van der Leun, Yvonne Erkens en Masja van Meeteren.

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Promotor: Prof.dr. M. Danhof

Promotores: H.A. Udo De Haes, P.M. Brakefield

In this work, we attempt to answer the question: