Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

Lezing

An interdisciplinary collection of the best international scholarship on Muslim youth.

Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Het belangrijkste doel van dit onderzoek is om de steden van het Romeinse Nabije Oosten in de keizertijd in kaart te brengen, met een focus op locatie, stadsgrootte en stedelijke kenmerken, om de vorm van het stedelijke systeem en de niveaus van integratie te bestuderen.

Op 8 september kwamen de studenten van de master European Law bijeen in de Lorentzzaal voor de feestelijke opening van hun programma.

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

The largest structures in the Universe are clusters of galaxies. Each can contain hundreds to thousands of galaxies.

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

In this thesis, we explore a Hochschild homology and cohomology-like notion for logarithmic schemes.

This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants⁠.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

This thesis is about cosmological inflation and its relation to observations.

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

This thesis combines field and laboratory studies to address some of the most pressing questions in the field of microplastic research.

This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

Kunst en vrije tijd, Kunst en vrije tijd

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

In cryptography, generic transformations are often used to strengthen simpler but weaker schemes, into more sophisticated and stronger ones.

The Utrecht-based VIDI project Lettercraft in Early Medieval Europe, AD 481-751 is working on a new database of Merovingian epistolary communication. We are looking for enthusiastic (R)MA students who would like to join us this Fall as research apprentices for the first phase of data entry and analysis.…

Op 30 oktober jl. bezochten de studenten van de advanced master International Children’s Rights het Internationaal Strafhof te Den Haag.

Op 25 oktober 2017, bezochten de huidige studenten van de advanced master International Children’s Rights van de Universiteit Leiden justitiële jeugdinrichting ‘De Hunnerberg’ in Nijmegen.

Voor studenten die graag een intermediair zijn tussen wetenschappelijke experts, beleidsmakers en politici op het gebied van duurzaamheid, is het masterprogramma Governance of Sustainabiliy wellicht precies wat ze zoeken. De Universiteit Leiden is voornemens deze nieuwe masterstudie in Den Haag te beginnen…

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Strictly for Business is een competitie om IT-professionals van bedrijven en universiteiten met elkaar in contact te brengen. Teams van 4 of 5 studenten, 2 'Young IT professionals' uit deelnemende bedrijven én een docent van de opleiding als coach strijden tegen elkaar. Uit Leiden hebben twee teams…

Tijmen richtte zich op de ontwikkeling van een screening platform waarop prostaatkankercellen worden onderzocht in een driedimensionale celkweek. De 3D celkweken bieden een betere fysiologische omgeving om stoffen te testen dan de 2D omgeving. Het platform is geoptimaliseerd voor gebruik met 384-wells…

Afgelopen maandag, 5 oktober, heeft prof. Tony Bovaird (Universiteit van Birmingham) een bezoek gebracht aan het Instituut Bestuurskunde. In het kader van het vak ‘Co-Production and Citizen Engagement’ (onderdeel van de Mastertrack ‘Public Management’) werd een mini-conferentie georganiseerd.

Students Practicing Citizen Journalism