Promotie

Ziekenhuisbacteriën die ongevoelig zijn voor antibiotica vormen een groeiend probleem. De Leidse antibiotica-expert Gilles van Wezel gaat samen met collega Michael Richardson en met experts van het LUMC en Naturalis op zoek naar nieuwe antibiotica in het gif van slangen en schorpioenen. Daarvoor krijgt…

Is het mogelijk om ziektes te diagnosticeren met behulp van moleculaire schakelaars? Over die vraag buigt het nieuwe internationale consortium LogicLab zich. Vanuit Leiden zijn scheikundige Sylvestre Bonnet en farmacoloog Thomas Hankemeier betrokken. Het project loopt voor vier jaar en krijgt ruim 3,5…

Voor Molecular Science and Technology is de matchingsactiviteit een verplicht onderdeel van de inschrijving.

Wil jij de beste redenen weten waarom je aan de Universiteit Leiden moet studeren? Of hoe het is om te leven in studentensteden zoals Leiden of Den Haag? Onze studenten vertellen je over hun studie aan de Universiteit Leiden.

Kunstmatige fotosynthese heeft als doel om via chemische processen zonne-energie om te zettn in brandstof. Semi-kunstmatige fotosynthese is een hybride aanpak waarbij chemische maar ook biotechnologische processen worden gebruikt. Wij hebben als doel om een hybride systeem te ontwikkelen met behulp…

Wil jij de beste redenen weten waarom je aan de Universiteit Leiden moet studeren? Of hoe het is om te leven in studentensteden zoals Leiden of Den Haag? Onze studenten vertellen je over hun studie aan de Universiteit Leiden.

MST biedt verschillende voorlichtingsactiviteiten –zowel in Leiden en Delft- om je te helpen bij je studiekeuze.

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Promotor: Prof.dr. A.G.G.M. Tielens

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Heb je nog vragen over de opleiding MST? Neem dan gerust contact met ons op!

Planets are formed in disks of gas and dust around young stars.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Het kwantificeren van lichamelijke activiteit (met behulp van versnellingsmeters) en het combineren van de frequentie en intensiteit van activiteiten met gezondheidsgegevens (hersen-MRI, traditionele klinische parameters en metabolomics) is van het grootste belang om mobiliteit en gezondheid bij oudere…

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf