Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.

Promotor: G. J. Kroes

Promotor: Prof.dr. M. Ubbink

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

De Staff Alliance for Equity (SAFE) is een bottom-upplatform dat openstaat voor medewerkers op alle niveaus, ongeacht hun contractuele status. De aanwezigheid en activiteiten van SAFE versterken onze toewijding aan de Gedragscode van de Faculteit Governance and Global Affairs, die ‘alle studenten en…

Duurzaamheid is een van de centrale aandachtspunten van de Universiteit Leiden en speelt een steeds grotere rol binnen het onderwijs en onderzoek van de Faculteit der Rechtsgeleerdheid. Binnen deze context levert de afdeling Sociaal Recht een belangrijke bijdrage aan het debat en onderzoek rondom Business…

Intelligente apparaten zullen ook ethische beslissingen gaan nemen. Mag een zelfrijdende auto voetgangers overrijden om de inzittenden te redden van een frontale botsing? Mag een onderhandelings-app stress in de stem van de tegenpartij detecteren? En wie bepaalt of dit mag, de gebruiker, de maker of…

De Leidse sociaal psycholoog Carsten de Dreu is door zijn benoeming als Distinguished Research Fellow verbonden aan de University of Oxford om mee te denken en te werken aan een groot onderzoek naar besmettelijke ziekte.

Antropoloog Erik de Maaker ontvangt een beurs voor onderzoekssamenwerking tussen India en Nederland voor het project 'Markets, Ethics and Agency.' De subsidie wordt ingezet voor onderzoek naar de toenemende integratie van de hooglanden van Zuid-Azië.

Ook in 2020 hebben veel van onze medewerkers en studenten mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.

This new Casebook features the work of an international, interdisciplinary research group entitled ‘The Joust as Performance: Pas d’armes and Late Medieval Chivalry’.

Digitale voortgangstoetsing als didactische methodiek.

Hij praat snel en enthousiast. Logisch, want Gerard van Westen is als de machinist op een heel snelle trein. Het eindstation: een virtuele mens, bestaand uit algoritmen die voorspellen wat een toegediende stof doet in ons lichaam. De trein is al een heel eind op weg. De farmaceutische industrie is ook…

Een techniek om CO2 om te zetten in brandstoffen en andere nuttige producten, is elektrolyse. Om dit efficiënt en op grote schaal te kunnen doen, moeten we wel precies begrijpen hoe elektrolyse werkt. Hoogleraar Marc Koper is expert op dit gebied.

Betekenisvol scheikundeonderwijs

Kunstmatige fotosynthese heeft als doel om via chemische processen zonne-energie om te zettn in brandstof. Semi-kunstmatige fotosynthese is een hybride aanpak waarbij chemische maar ook biotechnologische processen worden gebruikt. Wij hebben als doel om een hybride systeem te ontwikkelen met behulp…

De Faculteit der Wiskunde en Natuurwetenschappen heeft verschillende studieverenigingen, die zowel studiegerelateerde als sociale activiteiten organiseren voor studenten.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Curved single crystals provide variable, but well-defined surface structures.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Heterogeneous catalysis is essential to many industrial applications. These catalysts are often comprised of supported nanoparticles, which contain various different surface sites.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

Promotor: A. Kros

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

This thesis describes the design, characterization and application of dextran based crosslinked network.