Planets are formed in disks of gas and dust around young stars.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Democratie begint bij de gemeente. Daar ligt de bron van burgerschap, zeker in Nederland, zo schrijven Wim Voermans en Geerten Waling in het boek Gemeente in de genen, dat 20 februari verschijnt bij uitgeverij Prometheus.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

Microben, dat zijn toch ziekmakers? Moeten we daar niet vanaf? Nou, liever niet, weet microbioloog Ben Lugtenberg. Zonder microben gaan we namelijk dood. Na zijn eerste boek 'Zó leuk is microbiologie' is er nu 'Gezond met microben'. Voor dit boek heeft hij 35 expert gevraagd iets te schrijven over…

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

Promotor: Prof.dr. B. van de Water

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Promotor: M.K. Richardson, Co-Promotor: F. Witte

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotor: B. van de Water

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Promotor: Prof.dr. B. van de Water

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Promotor: E.F. Smets Co-promotor: J. Geml

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotor: B.van de Water, Co-promotor: L.S.Price

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

Sustainable energy from wind and solar is most readily available near the sea.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotor: J. A. Bouwstra

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Hoe helpen demonstratie-experimenten in de klas leerlingen om te leren chemisch redeneren?

Dit onderzoek gaat over het gebruik en de interpretatie van hoeveelheidsuitdrukking in verschillende talen, met name in relatie tot telbaarheid.

Als onderdeel van de Leidse Erfgoed Deal werkt de Gemeente Leiden samen met de Universiteit Leiden, Naturalis Biodiversity Center en Erfgoed Leiden en Omstreken aan onderzoek naar de klimaatopgave voor de binnenstad en de historische groen- en blauwstructuren. Het doel is om te verkennen hoe deze structuren…

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Jupiter is de vijfde planeet vanaf de zon en de grootste planeet van het zonnestelsel. De afstand tot de zon is 778 miljoen kilometer, waardoor een jaar op Jupiter 11,8 aardse jaren duurt. De dagen op Jupiter zijn wel korter dan op aarde: een dag duurt daar maar 10 uur.