Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Promotores: H. Schiessel, G.T. Barkema

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotor: Prof.dr. A.W. van der Vaart

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Promotor: S.M. Verduyn Lunel, Co-promotores: M.F.E. de Jeu, B. de Pagter

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

In this thesis we study bistable reaction-diffusion equations on lattice domains.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Promotor: Prof.dr. M.L. van Heck, Co-Promotor: B.P. Tighe

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

The applications of studying the early development of insects range from agriculture to material science.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotor: W. T. F. den Hollander, F. H. J. Redig

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Promotor: K.J. Batenburg

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.