Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Globally and regionally, biodiversity is declining and there are shifts in species’ occurrences and functional traits.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Consequences for sediment stability and seston trapping

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

Een nieuwe manier om het licht van verre planeten te analyseren zou ons bewijs kunnen leveren van buitenaardse planten, schrijft astronomie-auteur Colin Stuart in de New Scientist. In zijn artikel beschrijft hij het werk van de groep van de Leidse astronoom Rob van Holstein. Dit team detecteerde afgelopen…

This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

What holds people together and what makes them willing to fit within larger political structures? Our project examines this question in the practices of dynastic rulership in Eurasia ca. 1300-1800.

Security and safety challenges rank among the most pressing issues of modern times. Challenges such as cyber-crime, terrorism, and environmental disasters impact the lives of millions across the globe. The course will introduce you to this broad theme in an increasingly complex world.

Optimally solving real-world expensive Black-Box Optimization (BBO) problems w.r.t. real-world constraints, such as wall-clock time and computational costs, is extremely difficult and tedious.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

What are the pressing issues of our time, and how can different disciplines come together to address them? Studium Generale and Leiden University College (LUC) present the Global Challenges series: events that bring together researchers from LUC and experts from other disciplines to tackle a shared…

Discover the master program population Health Management at Leiden University and contribute to a more integrated health care system. Learn more!

Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

Op 16 juni 2020 verdedigde Andrea Varga haar proefschrift 'Establishing State Responsibility in the Absence of Effective Government'. Het promotieonderzoek is begeleid door promotoren prof. dr. N.J. Schrijver en prof. dr. F. Baetens (University of Oslo).

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Hifadhi ya Dijiti ya Ustadh Mau

Promotor: Prof.dr. C.U. Keller, Co-promotor: Frans Snik

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

Promotor: W.Th.F. den Hollander

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Research

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

Met een speciaal symposium in museum Boerhaave vierde ESO op maandag 26 september haar 60-jarig bestaan. Meer dan 100 wetenschappers, politici en mensen uit de industrie waren aanwezig om terug te kijken op samenwerkingen, mijlpalen en ontdekkingen. De Leidse astrochemicus Ewine van Dishoeck was één…

Sterrenkundige Ignas Snellen onderzoekt atmosferen van exoplaneten met als uiteindelijk doel aanwijzingen voor leven te vinden. Dat lukt steeds beter dankzij alsmaar slimmere meetmethoden van zijn onderzoeksgroep. ‘Binnen tien jaar wordt het echt spannend.’ Oratie 8 november.

Faciliteiten waar LIBC leden gebruik van kunnen maken (in het Engels):

Wat doet de Universiteit Leiden om haar gebouwen en campussen toekomstbestendig en onafhankelijk van fossiele energie te maken?

Gevolgen voor de klas en tips voor de leerkracht