The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Lezing

Overkleeft

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

De master Biology is een samenwerking tussen het Instituut Biologie Leiden, Naturalis en het Centrum voor Milieuwetenschappen Leiden waardoor het programma een brede en diverse scope heeft. De opleiding biedt zeven specialisaties, waarvan vier researchspecialisaties die nauw verbonden zijn met het onderzoek…

Promotor: J. Schaye

Trigonostemon Blume is a plant genus in the family Euphorbiaceae comprising 59 species.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Promotor: Prof.dr. P.C. van Welzen

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Studievoorlichting

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Aan de opleidingen van het Centre for Professional Learning op het gebied van Terrorisme, Recht en Veiligheid zijn verschillende (research) fellows verbonden. De fellows geven advies over de inhoud van het curriculum en de verbinding tussen wetenschap en praktijk.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

During the course of drug discovery translational steps are made.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Check hieronder de aanmelddeadlines voor de opleiding Molecular Science and Technology.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Prof. Hermen Overkleeft is bekroond met de 2015 Jeremy Knowles Award van de Royal Society of Chemistry voor zijn innovatieve en inzichtelijke ontwikkeling van activity-based eiwit probes voor de beeldvorming en de identificatie van enzymen in gezondheid en ziekte. Van Overkleeft is in Leiden verbonden…

The NWO-funded Vidi project “American foreign policy and liberalism” challenges the idea that the United States has created and sustained a “liberal international order” since World War II. It instead explores the ways in which illiberal ideologies – such as those underpinning racial hierarchy at home…

Sinds 2009 behaalden 91 kandidaten hun doctoraat in Creative en Performing Arts. Op deze pagina een overzicht van ACPA's alumni.

Dr. Bela Bode ontvangt van de Alexander von Humboldt-stichting de Feodor Lynen onderzoeksbeurs voor de ontwikkeling van nieuwe methoden voor verbetering van het signaal in de vaste stof NMR. Hij streeft naar een specifiek analytisch instrument voor oppervlakte-studies en onderzoek over membranen en…

Promotor: H.J.M. de Groot

Check de volgende toelatingseisen voordat jij je aanmeldt voor de opleiding Molecular Science and Technology.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Promotor: A. Kros

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…