A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Promotor: Prof.dr. P. Stevenhagen, Jan-Hendrik Evertse, Co-promotor: Pascal Autissier

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

We prove a p-adic version of the work by Gross and Zagier on the differences between singular moduli by proving a set of conjectures by Giampietro and Darmon, who investigated the factorisation of a rational invariant associated to a pair of CM-points on a genus zero Shimura curve, obtained as the ratio…

This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

Promotor: Prof.dr. M. Ubbink

During the course of drug discovery translational steps are made.

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

De pijnlijke geschiedenis van koloniale slavernij is lang onderbelicht gebleven. Mensen van wie de voorouders in slavernij leefden stellen nu kritische vragen over hoe we met dat verleden omgaan. Leidse onderzoekers bestuderen het koloniale en slavernijverleden en de langetermijnimpact daarvan op koloniaal…

In Zuid-Afrika zijn ongelijkheid en geweld de twee grootste problemen. Waar komen die problemen vandaan? Misschien hangen ze samen met rivaliserende groepen, misschien met economische factoren, met overheidsbeleid of met alle drie tegelijk. Om maatschappelijke problemen te begrijpen, is het belangrijk…

In samenwerking met het Afrika-Studiecentrum Leiden.

The basic program comprises a total of twelve courses organized by the Research School, that have been purpose-developed for training and support of PhD students and Research MA students who specialize in Medieval Studies (history, art history, and literary history, in particular).

Bouwen aan een levendige Humanities Campus met een groene buitenruimte die ontmoeting stimuleert.

Benieuwd welke kennis en vaardigheden jij leert tijdens de bachelor opleiding Koreastudies? Dat zie je in de opleidingsvideo. Bekijk 'm direct.

Onze AI-wetenschappers werken nauw samen met onder andere de TU Delft en de Erasmus Universiteit.

De masterspecialisatie South Asian Studies van de Universiteit Leiden is gericht op studenten die Zuid-Azië willen bestuderen vanuit diverse perspectieven, zoals geschiedenis, literatuur, kunst, media, cultuur, religie, filosofie en filologie.

Samenwerking ten behoeve van wetenschapsoriëntatie

Sinds 2009 behaalden 95 kandidaten hun doctoraat in Creative en Performing Arts. Op deze pagina een overzicht van ACPA's alumni.

Een masteropleiding vergroot je kansen op de arbeidsmarkt en opent deuren naar uitdagende functies. Na je driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master aan de Universiteit Leiden of een andere instelling.

Een masteropleiding vergroot je kansen op de arbeidsmarkt en opent deuren naar uitdagende functies. Na je driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master aan de Universiteit Leiden of een andere instelling.

Een masteropleiding vergroot je kansen op de arbeidsmarkt en opent deuren naar uitdagende functies. Na je driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master aan de Universiteit Leiden of een andere instelling.

The extensive use of electronic communication channels and other devices has opened new possibilities for collecting data on human behavior. This information is sometimes openly accessible, but largely part of administrative registration systems that are not open to the broader public. The data provides…

Een masteropleiding vergroot je kansen op de arbeidsmarkt en opent deuren naar uitdagende functies. Na je driejarige bachelor kun je direct doorstromen naar een één- of tweejarige master aan de Universiteit Leiden of een andere instelling.