Onderzoekers vanuit verschillende vakgebieden werken samen om oplossingen te bedenken voor maatschappelijke problemen.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Promotores: Prof.dr. D. Bouwmeester, Prof.dr. A. Fiore (TU Eindhoven)

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Studievoorlichting

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Promotie

Wetenschappers van de Universiteit Leiden hebben een doorbraak bereikt in de bestudering van de erfelijke stofwisselingsziekte van Pompe. Samen met hun Yorkse collega’s ontwierpen zij een molecuul dat zich bindt aan het enzym dat aan de basis staat van het ziekteverloop. De bevindingen zijn gepubliceerd…

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Promotor: J. Kuiper

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Promotores: A.H. Meijer, H.P. Spaink

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Promotor: Roeland M.H. Merks

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Nog altijd lukt het niet om alle kankerpatiënten van de juiste behandeling te voorzien. Oncode Accelerator wil daarom de manier waarop we kankerbehandelingen ontwikkelen innoveren: binnen het programma wordt de patiënt centraal gesteld. Universiteit Leiden en LUMC gaan hier samen met andere partijen…

Studies naar perceptuele besluitvorming presenteren dezelfde stimulus doorgaans herhaaldelijk tijdens een experimentele sessie, maar negeren de volgorde van deze observaties, waarbij wordt uitgegaan van een onrealistische stabiliteit van beslissingsstrategieën tijdens proeven. Maar zelfs ‘stabiel’,…

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.