Op zondag 6 augustus werd de Nederlandse vrouwenploeg voor het eerst Europees kampioen tijdens het EK voetbal voor vrouwen in eigen land. Tijdens het toernooi was er veel media-aandacht voor de rol van onze Leidse onderzoekers. Een overzicht.

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Promotor: C.J. ten Cate

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotor: S.M. Verduyn Lunel

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Arthur Elias, onderzoeker en 'onderwijsman' bij Rechtsgeleerdheid, heeft een koninklijke onderscheiding ontvangen. Bij zijn afscheid op 24 juni werd hij benoemd tot Ridder in de Orde van Oranje Nassau.

De gemeente Leiden helpt statushouders om zo snel mogelijk sociaal en economisch zelfstandig te worden, met behulp van vrijwilligers. Rechtenpromovenda Dorine Verheij is een van hen. Ook iets voor u?

Onlangs was UD Reijer Passchier te gast bij de Mr. Hans van Mierlo Stichting om met Laura de Vries en Daniël Schut een podcast op te nemen over de vraag: wie is de baas over onze data?

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

This thesis investigates Open-world Continual Learning (OWCL), a learning paradigm designed for intelligent systems operating in non-stationary environments with persistent exposure to unknown data.

Gebouwen zijn gesloten en al het onderwijs is online: het zijn vreemde tijden voor de studenten aan onze universiteit. Voor internationale studenten is de situatie nog net wat ingewikkelder. Zij zijn ver van hun vrienden en familie vandaan, en moesten beslissen of ze hier zouden blijven, of terugkeren…

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Als een pilletje zonder werkzame stofjes toch helpt, dan heet zo'n positieve verwachting een placebo-effect. Een negatieve verwachting heet een nocebo-effect. Beide zijn te sturen met verbale suggesties en conditionering. Deze combineren is volgens de onderzoeksgroep van Andrea Evers de meest veelbelovende…

Hevige regenbuien kunnen ervoor zorgen dat straten blank komen te staan en kelders en tunnels onderlopen. Jan van Rijn onderzocht met Christiaan Lamers (voorheen Universiteit Leiden) en Ton Beenen (STOWA, RIONED) hoe data science kan helpen te voorspellen welke gebieden een groter risico hebben op wateroverlast.…

In this project, researchers from computer science, law, psychology, and public administration research in practice how artificial intelligence (AI) can be leveraged to make decision-making in the security domain more effective, while also keeping it safe and accountable.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

CrO2, a half-metal ferromagnet, has shown great promise for superconducting spintronics applications for nearly two decades.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotor: Prof.dr. J. Kuiper

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…