The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

The applications of studying the early development of insects range from agriculture to material science.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotor: W. T. F. den Hollander, F. H. J. Redig

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Promotor: K.J. Batenburg

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Technologies that help to enhance our educational environments can be found everywhere.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Promotor: J. Kuiper

This dissertation advances automated negotiation by developing agents that can learn and adapt across diverse negotiation settings through three increasingly sophisticated approaches: automated algorithm configuration, portfolio-based strategy selection, and end-to-end reinforcement learning with graph…

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Promotores: T.H. Oosterkamp, N. de Jonge

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.

Kunst en vrije tijd, Kunst en vrije tijd