‘Schiedsgerichte in den Aussenverträgen der EU. Neue Entwicklungen unter Einbezug der institutionellen Verhandlungen Schweiz–EU’, Jusletter 28 mei 2018

Wat is er nodig om een mens te maken? Een uitdijend heelal. Gebouwd uit deeltjes, ruimte en tijd, en hun subtiele mechanismen.

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

Promotor: Prof.dr. M. Ubbink

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Today, knowledge is the most crucial element to stimulate organizational competitiveness and economic development.

Promotor: Prof.dr. J.P. Abrahams

Promotor: J.M. Memelink

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

COI@Leiden organises activities and events throughout the year. These include a monthly seminar series on topics relating to conflict resolution and PhD labs to assist COI students in developing their research skills.

This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

Nascholing en activiteiten voor natuurkundedocenten op het gebied van sterrenkunde.

Met ons onderzoek en onderwijs dragen we bij aan een betere wereld. Onze onderzoekers duiden ontwikkelingen in wetenschap en maatschappij, en helpen mee om oplossingen te vinden voor uitdagingen waarmee de samenleving zich geconfronteerd ziet.

De Universiteit Leiden is een internationaal georiënteerde en brede universiteit. We onderscheiden vijf wetenschapsdomeinen waarbinnen ons onderzoek en onderwijs plaatsvindt.

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

Promotor: Prof.dr. A. Achucarro

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

De onderzoeken aan het Leiden University Centre for Linguistics (LUCL) richten zich op taalvariatie en taaldiversiteit. Om zowel de maatschappelijke als de wetenschappelijke kennis over dit onderwerp te vergroten, zijn de onderzoeken ondergebracht in zes overkoepelende (en overlappende) onderzoeksprogramma’s.…

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

Veel van onze lezingen zijn opgenomen. Op deze plaats zullen ze beschikbaar zijn. Soms tijdelijk, soms voor langere tijd. De opnames bevatten zowel het beeld van de beeldpresentatie (als die er was) als een beeld van de sprekers.

Promotor: T. H. Oosterkamp

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

Ontmoet de mensen van het Resilience Center

Promotie

Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.

De studie Bio-Farmaceutische Wetenschappen richt zich specifiek op geneesmiddelenontwikkeling. Je bestudeert de (bij)werking van geneesmiddelen en kijkt naar de mechanismen van ziektes.

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

Kan het conditioneringsparadigma worden gebruikt voor kankerbehandeling met checkpointinhibitie?