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707 zoekresultaten voor “sara cell differentiatie” in de Publieke website

• 
  Cecilia Mignanti Promovendus / buiten

  Faculteit der Geesteswetenschappen

• 
  Yumeng Wang Promovendus

• T-cell gene therapy for low mutational burden cancer Agenda - 9 januari 2025

  Promotie

• Primary T-cell responses against SARS-CoV-2 in hematological patients Agenda - 12 februari 2026

  Promotie

• Onderzoekers Sociale Veerkracht en Veiligheid

  In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

• Exploring big data approaches in the context of early stage clinical Onderzoeksoutput

  Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

• Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice Onderzoeksoutput

  In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

• Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana Onderzoeksoutput

  Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

• Developing systems for high-throughput screening of infectious diseases using zebrafish Onderzoeksoutput

  Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

• Microglial lipid metabolism: a delicate balance Onderzoeksoutput

  Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

• CE-MS for metabolomics: advancing performance and detection sensitivity Onderzoeksoutput

  The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

• Cancer chess: molecular insights into PARP inhibitor resistance Onderzoeksoutput

  The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

• Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors Onderzoeksoutput

  Promotor: A.P. IJzerman

• Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management Onderzoeksoutput

  The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

• To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors Onderzoeksoutput

  Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

• Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor Onderzoeksoutput

  Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

• Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis Onderzoeksoutput

  This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

• Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors Onderzoeksoutput

  The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

• Piecewise deterministic Markov processes: an analytic approach Onderzoeksoutput

  Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

• The structure of a working catalyst: from flat surfaces to nanoparticles Onderzoeksoutput

  Promotor: Prof.dr. J.W.M. Frenken

• Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands Onderzoeksoutput

  Promotores: A.P. IJzerman, H.W.T. van Vlijmen

• Development of kinase inhibitors and activity-based probes Onderzoeksoutput

  Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

• Lipid bilayers decorated with photosensitive ruthenium complexes Onderzoeksoutput

  Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

• Direct and two-step activity-based profiling of proteases and glycosidases Onderzoeksoutput

  Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

• Allosteric modulation and ligand binding kinetics at the Kv11.1 channel Onderzoeksoutput

  Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

• Bioorthogonal tools to study fatty acid uptake in immune cells Onderzoeksoutput

  The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

• Wiskunde en Natuurwetenschappen

  Het onderzoek binnen de Faculteit der Wiskunde en Natuurwetenschappen omvat de disciplines wiskunde, informatica, sterrenkunde, natuurkunde, scheikunde, bio-farmaceutische wetenschappen, biologie en milieuwetenschappen.

• Onderzoeksoutput

• 
  Max Fernkorn Onderzoeker

• 
  Jingchao Wu Onderzoeker

• 
  Nina Schulten Onderzoeksanalist

• 
  Yuting Wang Gast

• 
  Andreea Iosif Analist

• 
  Micha Drukker Hoogleraar

• 
  Eliane Züger Promovendus

• 
  Rafaella Buzatu Promovendus

• 
  Yubin Guo Promovendus / gast

• 
  Ferdinand Teichert Promovendus / gast

• 
  Ruben de Vries Promovendus

• 
  Benjamin Tak Promovendus

• 
  Joey Zuijdervelt Promovendus

• 
  Daan Vlemmings Analist

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• Diversiteit in onderzoek en onderwijs Dossier: Diversiteit en inclusie

• Slice of Science Dossier: 444 jaar Universiteit Leiden

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• De Geschiedenis van het Integraalbegrip (geannuleerd) HOVO

• 
  Rafaël Vos Gast-onderzoeker

• 
  Nicolas Turner Docent

  Faculteit der Geesteswetenschappen

• 
  Gislene Da Silva Trindade Buitenpromovendus

  Faculteit der Geesteswetenschappen