Uitgaansgeweld, seksueel geweld, huiselijk geweld…een samenleving zonder een vorm van gewelddadig gedrag is haast ondenkbaar. De wetenschap is dan ook al lange tijd bezig met geweld en geweldsbeheersing. Een belangrijk werkveld, maar het ontbrak aan een overzicht van wetenschappelijke en praktijkgerichte…

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotor: Prof.dr. B. van de Water

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Promotor: Prof.dr. T. Hankemeier

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

De Universiteit Leiden heeft onderzoeksinstituten gevestigd in Leiden en Den Haag.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

In dit project gebruiken we sociale netwerkanalyse om het gedrag van gebruikers op online fora en bijbehorende marktplaatsen in de tijd te analyseren.

In de onderzoekslijn Geneesmiddelenonderzoek werken we voornamelijk met knaagdieren. Knaagdieren, zoals muizen, worden veel gebruikt als proefdier. Deze kleine zoogdieren zijn makkelijk te houden en planten zich snel voort.

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Promotor: Prof.dr. J. Kuiper

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

De Faculteit der Wiskunde en Natuurwetenschappen is gevestigd op verschillende locaties in het Bio Science Park Leiden.

Promotor: J. Kuiper

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Preterm birth is a major contributor to neonatal morbidity and mortality and is associated with both acute complications and long-term health consequences.

Promotores: W. Jiskoot, F. Ossendorp

This thesis examines strategies to address the global threat of antimicrobial resistance (AMR). Antimicrobial resistance poses an increasing global health risk, highlighting the need for new treatments against Gram-negative pathogens.

In this thesis the links between allergy and intestinal health, the gut microbiome (GM), and external factors were studied by exploring the metabolome in longitudinal clinical studies and in vitro models.

In dit proefschrift onderzochten we hoe we kankerbehandelingen slimmer en veiliger kunnen doseren. Veel middelen worden nog volgens een “one size fits all”-schema gegeven, vaak gebaseerd op de maximaal verdraagbare dosis. Dat kan leiden tot onnodig veel bijwerkingen, behandelingonderbrekingen en hoge…