Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Promotor: Prof.dr. F. den Hollander, G.Maillard

During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Promotores: Bas Edixhoven, Guy Henniart

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

Promotor: Prof.dr. M. Ubbink

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Promotor: Prof.dr.ir. E. Deprettere

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

The Study Information Committee works to create a positive and accurate picture of the bachelor and master programs offered by the Institute of Biology Leiden (IBL). The committee consists of IBL staff members and study ambassadors. We reach out to future and current students, high school biology teachers,…

Het Europaeum is een netwerk van 17 vooraanstaande Europese universiteiten, met als doel om talentvolle studenten en docenten met elkaar in contract te brengen en door samenwerking en academische mobiliteit een 'Europees gevoel' te bevorderen.

Promotor: Bas Edixhoven, Promotor: Qing Liu

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Lezing

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)