In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Dit project beoogt de ontwikkeling van geavanceerde data-analysemethoden voor monitoring en het vergroten van ons inzicht in de dynamiek van de biodiversiteit in natuurgebieden zoals de Oostvaardersplassen.

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

Bij LIACS erkennen we de groeiende behoefte aan geavanceerde technische ondersteuning bij onderzoeksprojecten en labonderwijs. Toenemende studentenaantallen, steeds geavanceerdere hardware en infrastructuur, nieuwe eisen rondom dataveiligheid en -beheer, en de complexiteit van de kerncursussen informatica…

Promotor: A.P.IJzerman Co-promotor: A. Bender

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

Promotor: G. J. Kroes

Promotor: M.A.G.J. Orrit

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.

Promotor: Prof.dr. M. Ubbink

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

This thesis aims to test in vitro pipelines to rapidly and cost-effectively identify molecular mechanisms that drive adverse outcomes in clinical use.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Promotor: Prof.dr. J.N. Kok

Acht wetenschappers van de Universiteit Leiden hebben een beurs toegekend gekregen van wetenschapsfinancier NWO. Met deze Vidi-financiering kunnen de onderzoekers de komende vijf jaar een vernieuwende onderzoekslijn opzetten en hun eigen onderzoeksgroep verder uitbouwen.

Van waterzuiveringsinstallaties tot een lekkere warme douche, de CO2-uitstoot ten gevolge van het watergebruik in de VS staat gelijk aan dat van 50 miljoen auto’s die een jaar lang rondrijden. In The Washington Post raadpleegt journalist Tik Root verschillende experts om te leren over manieren om ons…

Veel belangrijke onderwerpen in de informatica, zoals de juistheid van software, de efficiëntie van algoritmen en de modellering van gecompliceerde systemen, zijn afhankelijk van een goede theoretische onderbouwing. In de Theoriegroep bestuderen we deze fundamentele bouwstenen en ontwikkelen we verificatiemethoden…

De Faculteit der Wiskunde en Natuurwetenschappen streeft naar impact van haar onderzoek en onderwijs op de samenleving. Daarvoor werkt de faculteit in binnen- en buitenland samen met andere universiteiten en instituten, maatschappelijke partners, het bedrijfsleven én met het brede publiek.

Leidse biologiestudenten hebben de herkomst van exotische Alpenwatersalamanders in Nederland bepaald met een speciale DNA-techniek.

Veel belangrijke onderwerpen in de informatica, zoals de juistheid van software, de efficiëntie van algoritmen en de modellering van gecompliceerde systemen, zijn afhankelijk van een goede theoretische onderbouwing. In de Theoriegroep bestuderen we deze fundamentele bouwstenen en ontwikkelen we verificatiemethoden…

Leids rechtshistorisch onderwijs

De onderzoeksgroep Business, Technology & Public Policy van de afdeling Bedrijfswetenschappen van Universiteit leiden houdt zich bezig met het onderzoeken van de dynamische wisselwerking tussen ‘nieuwe’ technologieën en de verschillende belanghebbenden die hiermee interacteren, waaronder consumenten,…

Onderzoekers van LIACS werken aan het bedenken van de computers van morgen die de ruggengraat zullen vormen van de Cloud en Edge computing paradigma’s en ‘the Internet of Things’. In dit verband zijn we betrokken bij onderzoek en ontwikkeling van high performance computing systemen, embedded & real-time…

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Promotor: C. W. J. Beenakker, Yu. V. Nazarov, Co-promotor: J. Tworzydlo

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Promotor: Prof.dr. G.P. van Wezel

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Promotores: Prof.dr. F.S. de Boer, Prof.dr. J.J.M.M. Rutten (Radboud Universiteit Nijmegen)

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

The expanding population and economic activity are driving up global energy consumption. Simultaneously, there is an urgent need to transition from fossil fuels to renewable sources to mitigate the climate crisis, primarily caused by fossil fuel combustion.

Reconstructie van de taalgeschiedenis door onderzoek naar taalverandering.

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…