This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Promotie

Promotor: Prof.dr. G.P. van Wezel

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?

Rechtsgeleerdheid, Instituut voor Privaatrecht

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Minister Edith Schippers van Volksgezondheid investeert de komende vier jaar ruim 6 miljoen in onderzoek naar nieuwe antibiotica. Het programma wordt opgezet door diverse partijen, waaronder het Leidse Centre for Antimicrobial Research.

De Faculteit der Wiskunde en Natuurwetenschappen streeft naar impact van haar onderzoek en onderwijs op de samenleving. Daarvoor werkt de faculteit in binnen- en buitenland samen met andere universiteiten en instituten, maatschappelijke partners, het bedrijfsleven én met het brede publiek.

Meerdere consortia waarin de Universiteit Leiden is vertegenwoordigd gaan aan de slag met interdisciplinair onderzoek waarmee wetenschappelijke en maatschappelijke doorbraken binnen bereik komen. In de projecten werken kennisinstellingen, overheden en private partijen nauw samen.