This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Nature, nurture and neural mechanisms of social emotion regulation in childhood

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Kunst en vrije tijd, Kunst en vrije tijd

This study tests whether behavioural problems at a young age are related to early reading and mathematics development.

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Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

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This study’s main aim is to test whether children’s learning behaviour explains why they do not benefit from a literate environment.

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Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Op vrijdag 16 februari wordt het boek "Woodcuts as Reading Guides: How Images Shaped Knowledge Transmission in Medical-Astrological Books in Dutch (1500-1550)", geschreven door Andrea van Leerdam, bij de KB gepresenteerd. De presentatie is gratis en voor iedereen toegankelijk. Wel is het nodig om te…

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Studievoorlichting

This conference explores how reading experiences were shaped both by producers and users of vernacular books. By adopting an international and interdisciplinary perspective (combining book history, literary history, art history, religious studies, and history of knowledge) it aims to contribute to the…

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

De onderzoeksgroep Terrorism and Political Violence van de Universiteit Leiden bestudeert de oorzaken van radicalisering, de tactieken van extremistische groeperingen, en de effectiviteit van anti-terrorismebeleid. We onderzoeken ook de rol van media en de invloed van postkoloniale erfenissen in de…

Recently, a new edition of the ELS bulletin was sent out. Furthermore, we are thrilled to share the Midterm Report of the ELS lab @Leiden with you!

This thesis discusses the discovery potential of Intensity Frontier experiments.

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

In the first half of the sixteenth century, the Low Countries saw the rise of a lively market for practical and instructive books that targeted non-specialist readers. This study shows how woodcuts in vernacular books on medicine and astrology fulfilled important rhetorical functions in knowledge communication.…

Maandelijks interviewen we een student of medewerker van de Universiteit Leiden over hun werk of studie in relatie tot duurzaamheid.

Learning a programming language is challenging. Even one of the first –but crucial– concepts to learn, variables, is hard to grasp. Variables can represent different roles and functions within a code and need to be named appropriately to support code comprehension and debugging.

Een bachelor Security Studies doen en tegelijkertijd twee bedrijven opzetten en runnen: student Mohamed Sulaiman is altijd aan het werk. Maar dat doet hij met plezier en toewijding. Bij ondernemershub PLNT Den Haag krijgt hij hulp en doet hij inspiratie op.

Deze colleges zijn in het Engels, u kunt vragen stellen en reageren in het Nederlands.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Religious Studies at Leiden University allows you to study a broad spectrum of religions and their manifestations.

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Publicaties van het Leids Papyrologisch Instituut

In het voorjaarssemester biedt het NIMAR universitaire en hbo-studenten twee engelstalige tracks van 30 EC. Bij beide tracks ligt de focus op het bevorderen van taal- en linguïstische vaardigheden, maar de tracks bieden ook een diepgaande kennismaking met de Marokkaanse cultuur en samenleving.

Graduation MIRD Class of 2024: 'The world is better off with students like this'

Het LAK biedt verschillende schrijfcursussen aan. Maak kennis met de wereld van verhalen verzinnen. Leer de basisvaardigheden van fictie schrijven en leer als schrijver je eigen stem vinden en zet de eerste belangrijke stap van een idee naar een verhaal. Of maak kennis met poëtische technieken. De keuze…

eLaw onderzoekt de rol van het recht in de informatiemaatschappij: hoe kan het recht bijdragen aan een goede werking van informatie- en communicatietechnologie, en het gebruik ervan door burgers, bedrijven en overheden?

Kunst en vrije tijd, Kunst en vrije tijd

Kunst en vrije tijd, Kunst en vrije tijd

Biopolymer sequencing with graphene edge-based tunnel junctions has the potential to overcome current limitations with the third generation of sequencing based on biological nanopores.

De programmagroep Leer- en Gedragsproblemen in het Onderwijs doet onderzoek naar stagnaties die kunnen optreden in de cognitieve ontwikkeling.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Presents a novel philosophical account of psychedelic experiences, arguing that they can be induced by means other than psychedelics — such as meditation and yoga.