Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Dynamical systems describe the evolution of objects in a space over time and may be used to model physical phenomena. Due to this, much research is dedicated to understanding the mathematics of dynamical systems.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

This thesis studies operator-algebraic aspects of subproduct systems, a generalization of product systems of Hilbert spaces.

Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

We are living in an information era where the amount of image and video data increases exponentially.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Promotores: W. Jiskoot, F. Ossendorp

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Het Computer Systems, Imagery & Media (CSI) onderzoeksprogramma voert fundamenteel onderzoek uit naar methoden en technieken voor het ontwerp, de implementatie en de applicatie van geavanceerde computersystemen.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

This dissertation is organised into three parts, each addressing a distinct research area related to Gibbs measures.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.