The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

We study the physics of a broad range of biological and soft materials

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…

Addressing the core novel objective of scalably assessing the impact of possible interventions through counterfactual prediction based on spatio-temporal data.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

DSE 2.0 concerns research on DSE techniques for complex dCPS

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

The financial system needs complexity theory to predict economic crises like the 2008 meltdown. An international team of scientists, including Leiden physicist Diego Garlaschelli, state this in a paper published in Science on February 19th.

How can complexity science advance intelligence transformation?

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

For the first time, astronomers have detected the presence of complex organic molecules, the building blocks of life, in a protoplanetary disc surrounding a young star. The discovery reaffirms that the conditions that spawned the Earth and Sun are not unique in the Universe. The results are published…

What are the functions of the endocannabinoid system?

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

The authors of the article expect automation to improve accuracy in less complex programmes but worsens with increased complexity

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.

Promotor: S.M. Verduyn Lunel

In this thesis, we show that we can use Shimura’s CM theory to explicitly compute the Hilbert class field of any primitive quartic CM field.

How do balanced lethal systems originate and persist in nature?

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

Prof. Ton Liefaard and dr. Stephanie Rap (together with Apollonia Bolscher LL.M.) are involved in developing a training Toolkit and Manual for the project Improving Juvenile Justice Systems in Europe: Training for Professionals (JUST/2013/FRC/AG).

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotor: Peter Stevenhagen

Promotor: E. Bouwman, Co-promotor: S. Bonnet

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

About 15 km to the south of the ancient city of Petra, archaeologists from the University of Leiden have discovered an impressive network of ancient water conservation measures and irrigated field systems.

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Essays in Archaeology and Assyriology Dedicated to Diederik J.W. Meijer in Honour of his 65th Birthday

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.