Heart failure is a major health care problem with high mortality.

New technology offers many new possibilities for research, such as on dementia. ‘Organ-on-a-chip’ is a new technology in which small bits of organ are grown out of stem cells on a small plastic plate. A small piece of blood vessel, heart or nerve offers many new possibilities for research, such as…

With a Vici grant of 1.5 million euros, Professor of Mathematical biology Roeland Merks will look for ways to fix messy and leaky blood vessels in tumours. His research combines mathematical simulations and lab experiments in a unique way.

Researchers at Leiden University have demonstrated that tumours can apply mechanical means to attract the blood vessels they need to be able to grow. The team published this discovery on 2 March in Nature Scientific Reports.

PhD candidates in medicine, Wouter Jan Geelhoed and Nan van Geloven, are the winners of the Leiden preliminary round of FameLab. They are through to the final on 22 April.

In her inaugural lecture on 11 September, Miranda van Eck, Professor of Cardiovascular and Metabolic Therapeutics, addressed her research related to developing medications to keep our blood vessels clean.

Fishes rely heavily on sound to find their way during migration or dispersal. Many species are affected by noise pollution. Hans Slabbekoorn from the Institute of Biology Leiden received a HORIZON2020 grant of 500,000 euros to study the impact of sound conditions on movement decisions of fishes.

Sonja Boas developed new techniques to study vascular growth computationally. The results of her research provide a better understanding into mechanisms behind vascular growth, which is relevant to the development of medical therapies. She defends her thesis 'Computational modeling of angiogenesis'…

Promotor: Prof.dr. R.M.H. Merks

Tiny selenium particles could have a therapeutic effect on ischemic brain strokes by promoting the recovery of brain damage. Pharmacologists, including Alireza Mashaghi from the Leiden Academic Centre for Drug Research discovered that selenium nanoparticles inhibit molecular mechanisms that are responsible…

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Do natural soundscapes affect migratory decisions of fishes moving up and down rivers and is this process disturbed by vessel sounds?

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

It is with great pleasure that we present to you the second volume of Inter-Section, published in 2017.

Atherosclerosis (thickening of the artery wall) is the most common cause of heart attacks or strokes, and one of the most common causes of death in the western world. People with this condition have to take medicine all their lives, so a vaccine for atherosclerosis would be a breakthrough.

The project XAIPre (pronounce “Xyper”) aims to develop predictive maintenance system for the maritime industry using sensor technology and artificial intelligence. The project aims at developing Explainable Predictive Maintenance (XPdM) algorithms that do not only provide the engineers with a prediction…

Promotor: Prof.dr. J. Kuiper

A study of the technology, form, function, and use of pottery from the settlements Uitgeest-Groot Dorregeest and Schagen-Muggenburg 1, Roman Period, North-Holland, the Netherlands

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

The Cryogenics Department has a liquid helium production unit and an automatic liquid nitrogen filling plant.

We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…

Browse the latest articles and issues of Inter-Section.

Understanding Late Neolithic Ceramic Containers from Upper Mesopotamia

The following master research projects are currently open in the Bouwmeester group.

The research of our group is centered around dynamical systems, functional analysis and their interplay.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

Ceramics and Society in the Aegean from the 7th to the 20th century A.C. A Case Study from Boeotia, Central Greece (2003)

Archaeometric analysis of glazed pottery assemblages from the Early Byzantine to the Early Modern periods in the Aegean.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

Leiden Journal of Pottery Studies 22, 2006

Promotor: Roeland M.H. Merks

Serial learners: interactions between Funnel Beaker West and Corded Ware communities in the Netherlands during the third millennium BCE from the perspective of ceramic technology

On the 23rd of June Arianna Sacco successfully defended a doctoral thesis and graduated.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

PhD defence

Leiden Journal of Pottery Studies 23, 2007

Material Culture, Settlements, and Landscapes from the Mediterranean to Western Asia

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

A seven-metre glass tunnel, filled with running water, and equipped with speakers and cameras. An artificial river for investigating what light and sound pollution do to migrating fish.

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

The sustainability upgrade of the University Library (UB) is well under way. The building now has entirely new façade glazing with HR++ glass, as well as two new glazed roof domes. The climate-control system has also been modified, enabling low-temperature heating and enabling the building for connection…

The goal of the ANASTASIS project is the analysis and publication of early medieval (Merovingian) cemeteries in the Netherlands (c. 500 – 750 AD).

Papers written on the occasion of the 30th anniversary of the institute of Prehistory, Volume II.