This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Cardiovascular disease is the leading cause of death worldwide.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

The research at The Metabolomics & Analytics Centre is centered around developing innovating analytical methods to enable metabolomics-driven systems biology in personalized health strategies.

Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.

Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

This master specialisation is ideally suited as a basis for starting a research career at a university or research institute and for a position in a bioscience-based company.

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Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.

The Wadi al Jizzi Archaeological Project is a systematic and long term archaeological surface survey project, investigating the rich archaeological heritage of the Wadi al Jizzi region (Oman) from the Paleolithic until the early Modern period.

Single-layer graphene (SLG) has attracted considerable interest as a proton exchange membrane for direct methanol fuel cells (DMFCs), owing to its atomic thickness, mechanical robustness, and unique proton permeability.

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

Factors affecting galanthamine production in Narcissus

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

The Protein Centre can supply you with purified proteins that are essential for many experiments, ranging from in vitro inhibitor screening and enzymatic analysis to manipulation of life cells.

This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…

Division contact information & address

Tumours act like mini-organs, manipulating their environment and using bodily processes to survive and metastasise. Through research by Erik Danen and his colleagues, we are learning more about the complex nature of tumour cells. In the Dutch newspaper NRC, the scientists discuss their findings.

Supervisor: Andrea Martella

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Key publications of the Cancer Drug Target Discovery group

Promotor: E. Bouwman, Co-promotor: S. Bonnet

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)