Interaction between Legal Systems acknowledges that law-making and law enforcement are increasingly taking place on various levels: in a global context, in EU context, on a national level and in a private law framework. These levels influence each other, sometimes directly, on the basis of a hierarchical…

Piet van der Graaf was appointed as Professor of Systems Pharmacology in 2012. He is also Vice President and Head of Quantitative Systems Pharmacology (QSP) at Certara.

This thesis studies operator-algebraic aspects of subproduct systems, a generalization of product systems of Hilbert spaces.

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

Radical books on Islam glorifying armed jihad and humiliating Jews and Christians are available in the Vught prison library.

Researchers at the Institute of Criminal Law and Criminology - Paul Nieuwbeerta, Anouk Bosma, Esther van Ginneken, Hanneke Palmen and Maria Berghuis - have received 800,000 euro from the Dutch Custodial Institutions Agency (DJI) of the Ministry of Security and Justice to investigate living conditions…

The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Grammatical gender is famously the most puzzling of the grammatical categories. We have a solid typology of gender systems, yet exciting and unexpected patterns keep turning up which defy easy classification and straightforward analysis. Some of these question, stretch or threaten to cross the outer…

We study the physics of a broad range of biological and soft materials

This book explores the boundaries of the category of gender and their theoretical significance within the framework of Canonical Typology.

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

DIGIFOOD is a transnational research project that investigates how data governance can support equitable and sustainable digital food systems. Around the world, digital technologies are transforming agriculture. Sensors in soil, satellites in space, and mobile phones in farmers’ hands are generating…

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

In dit unieke uitwisselingsinitiatief volgen studenten van de Faculteit Rechtsgeleerdheid samen met gedetineerde personen een vak, binnen de muren van de gevangenis.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Research into research improves the academic system. CWTS studies and evaluates the academic system in various ways. One way is to provide information on the productivity and impact of academics by documenting how many publications they or their universities produce and how often these publications…

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

In this article, Marco Cinelli, assistant professor at Leiden University College The Hague, examines proper and improper uses of Multiple Criteria Decision Analysis (MCDA) methods in energy systems analysis.

Is system thinking through perspectives the solution for biology education to help students see the connections between different topics?

Increasing above- and belowground biodiversity in arable leek cultivation to stimulate pest control by natural enemies.

An important hormone excreting gland in the human body is the pituitary

On 5 September 2019, Jennifer Doekhie defended her thesis 'Dimensions of desistance: A qualitative longitudinal analysis of different dimensions of the desistance process among long-term prisoners in the Netherlands'. The doctoral research was supervised by Prof. P. Nieuwbeerta.

Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Despite various initiatives it appears that it is no simple task to get ex-prisoners back on the job market.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…