Source: Mediators Inflamm (2014)

When you apply for admission, you’ll be asked to submit several documents.

Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:

The master’s programme Biology at Leiden University offers seven specialisations ranging from Cell Biology to Molecular Genetics. The programme prepares you for a career in research within or outside academia.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

This thesis investigates how non-genetic factors, such as inflammation and concomitant medication, impact hepatic drug metabolism and subsequent drug metabolizing phenotype predictions.

Starting from Husserl’s somewhat controversial claim about the immortality of the constituting subjectivity, this thesis uses the limit-case of death in order to present a phenomenological exploration of the notion of subjectivity and its relationship to nature. It also offers a second-order discussion…

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

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Microbes influence and respond to other organisms. This theme explores the dynamic relationships within plant and animal microbiomes, and the immune responses that govern host defense. Using model systems such as zebrafish, insects, and plants, we investigate fundamental processes and engineer microbes…

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

The two-year Bioinformatics programme (120 EC) includes mandatory core courses and electives, as well as a Master's Thesis Research Project. PLEASE NOTE: The specialisation Bioinformatics will no longer accept new students after February 2026. If you're starting date is September 2026 or later, we…

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

Do understudied animals contain hidden species?

To be eligible for Molecular Genetics and Biotechnology at Leiden University, you must meet the following admission requirements.

Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Promotor: Prof.dr. C.A.M.J.J. van den Hondel, Dr. ir. V. Meyer, Co-promotor: Dr. A.F.J. Ram

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

Your time at Leiden is about more than just studying. Some of your best experiences will stem from being a part of our lively and diverse student community, as well as from life in the beautiful city of Leiden.

In this master programme you learn interdisciplinary approaches to address scientific and societal challenges in the field of (bio)medical sciences. The research in our programme Biomedical Sciences relates to the maintenance of health and prevention of disease. You will acquire a skill set suitable…

We are committed to provide you a meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

PhD defence

PhD defence

Promotores: J. Jonkers, K.E. de Visser

Human measures to protect lions have an impact on the genetic health of populations. Leiden and Kenyan scientists discovered this by analysing the DNA of 171 Kenyan lions. ‘By fencing reserves, for example, the chance of inbreeding increases.’ With the knowledge and tools from the research, management…

In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

It was already known that social anxiety disorder often affects more than one person in the same family. But research by PhD student Janna Marie Bas-Hoogendam has now shown that there are genetic brain characteristics that are associated with social anxiety. The PhD ceremony will take place on 14 Ja…

An international group of scientists, led by Leiden physicist Sense Jan van der Molen, has developed the first switchable molecular diode. You can turn this on and off through humidity. Vice versa, it is a humidity sensor at the nanoscale. Publication on 4 December in Nature Nanotechnology.

Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.

The mission of the Plant Sciences cluster is to contribute to the sustainable production of high-quality crops, flowers and high-value bio-based products, and to contribute to the maintenance and restoration of biodiversity in natural ecosystems. This is realised by generating fundamental knowledge…

Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).