This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Research in the POD-group addresses all features of random phenomena – modelling, structuring, analysis, control, optimisation – and covers both fundamental and applied aspects.

A full overview of MCBIM PhD theses.

Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…

Supervisor: Gerard van Westen

Current research at the Skin Barrier and Vaccination group.

On 29 June 2017, Carl Mair defended his PhD dissertation “Taking Technological Infrastructure Seriously”. The supervisors are Professor A. Schmidt and Professor G.J. Zwenne.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotor: J. Schaye

On 12 Februari 2019, Tobias van der Wal defended his thesis 'Nemo condicit rem suam'. The doctoral research was supervised by Prof. mr. W.J. Zwalve.

Promotores: S.F. Portegies Zwart, E. M. Rossi

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

In this thesis,

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

Galaxies in the local Universe fall into two main categories of spirals and ellipticals. In this Thesis, we explore the structural evolution of galaxies into this bimodal distribution.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Promotor: Prof.dr. F. den Hollander

This dissertation is organised into three parts, each addressing a distinct research area related to Gibbs measures.

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

Promotores: J.N. Kok, H.J. Hoogeboom

In the first part of this thesis we study the geometry of folding patterns.

This book explores the boundaries of the category of gender and their theoretical significance within the framework of Canonical Typology.

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

Promotores: J.J.M.M. Rutten, F.S. de Boer, Co-promotor: M.M. Bonsangue

Promotor: Prof.dr. F.S. de Boer

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

The ability to count is a property not often attributed to materials, despite the abundance of memory in materials. Regardless of how a material stores information, it is often difficult to retrieve exactly ‘what’ a material remembers.

Our in-house human skin equivalents contain all stratum corneum (SC) barrier lipid classes, but have a reduced level of free fatty acids (FAs), of which a part is mono-unsaturated. These differences lead to an altered SC lipid organization and thereby a reduced barrier function compared to human skin.…

Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame

Promotor: Prof.dr. D. Bouwmeester, Co-promotor: M.P. van Exter

Within this project, PeptoMiktoStars were realized through an orthogonal protecting group strategy and should be investigated further regarding their potential as drug delivery systems in the field of drug delivery to inflamed areas in cancer, bacterial infections or autoimmune diseases.

On February 7th, Lotte Dros-Hendriks succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Lotte on this great result.

Studying the underlying principles of the nature of language.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

The programme places emphasis on the interrelation of regional economic law of the European Union with global or trade law of the World Trade Organisation.

On 26 June 2019, Teun van der Linden defended his thesis 'Aanvullend Verrijkingsrecht'. The doctoral research was supervised by Prof. Jac. Hijma.

On 22 November 2018, Teico Sikkema defended his thesis 'Beginsel en begrip van verdeling'. The doctoral research was supervised by Prof. mr. W.G. Huijgen and Prof. dr. F. Sonneveldt.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

For some years, large tech companies have breached copyright law by using creative expressions from artists to train AI tools. Dirk Visser, Professor of Intellectual Property Law, spoke to ‘Financieele Dagblad’: 'Artists may lose the motivation to create new art.'

Central in coordination and organometallic chemistry is the synthesis of new chelating ligands, the synthesis and characterization of metal complexes with these ligands, and the study of their properties. An important goal in my research is to create understanding of the relation between the structures…

Information about the products of the extract library.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

On 27 May 2021, Hirad Abtahi defended his thesis 'Adjudicating Attacks Targeting Culture'. The doctoral research was supervised by Prof.dr. C. Stahn.

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.