Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

The programme group Research Methods and Statistics offers support to researchers from a variety of research projects within Education and Child Studies.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotores: J.C. van Houwelingen, S.A. van de Geer

Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The symposium is open to all registered participants and consists of a one-day programme and a poster session.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

‘Regenerative medicine’ explores ways to repair or replace damaged cells, tissues and organs with cell, stem-cell or gene therapy. It can lead to valuable breakthroughs in the treatment of chronic diseases such as diabetes, heart problems and kidney diseases or muscle diseases.

All crested and marbled newts (the genus Triturus) suffer from an unusual genetic abnormality, called a balanced lethal system, that kills exactly half of their offspring. How can a trait so disadvantageous have survived millions of years of natural selection?

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen

The vegetative growth period for leafy vegetables like lettuce is essential for yield and quality.

To be eligible for Comparative Criminal Justice at Leiden University, you must meet the following admission requirements.

PhD defence

Our lectures are open to anyone with an interest Find your inspiration for interdisciplinary research

To be eligible for Biodiversity and Sustainability at Leiden University, you must meet the following admission requirements.

To be eligible for Biology at Leiden University, you must meet the following admission requirements.

To be eligible for Biology and Business Studies at Leiden University, you must meet the following admission requirements.

To be eligible for Molecular, Cellular and Organismal Biology at Leiden University, you must meet the following admission requirements.

To be eligible for Biology and Education at Leiden University, you must meet the following admission requirements.

To be eligible for Molecular Genetics and Biotechnology at Leiden University, you must meet the following admission requirements.

To be eligible for Evolutionary Biology at Leiden University, you must meet the following admission requirements.

To be eligible for Biology and Science Communication and Society at Leiden University, you must meet the following admission requirements.

We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Are you looking for a research project? We have projects available for motivated 6–9-month internship students with particular interest in organic/polymer synthesis, formulation development, gene delivery, protein delivery, and the preliminairy in vitro screening of drug delivery platforms. Students…

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

PhD at Université de Picardie Jules Verne, Amiens - France

Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.

Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…

Delineating psychophysiological endophenotypes of social anxiety disorder

The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

Nowadays, most Europeans speak a language belonging to the Indo-European language family. However, very different languages were spoken on our continent before the arrival of the Indo-Europeans. The EUROLITHIC project tries to find answers to the question which languages these were and where they came…