Studies in Early Near Eastern Production, Subsistence, and Environment, vol.16. Edited by Noriyuki Shirai.

Promotor: Prof.dr. P. Hooykaas, Co-promotor: Dr. R. Offringa

Antwoord op veelgestelde vragen over onderzoek met proefdieren bij de Universiteit Leiden. FAQ

Which genes are involved in woodiness and associated traits such as drought tolerance, flowering time, stem elongation, life span, and plant herbivory, and how do these gene regulatory pathways overlap?

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The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

The INTERACT project strive to unlock the enormous biotechnological potential of microbes, leading to sustainable crop productions systems.

Research lines within the Pharmacy group:

The research programme Probability Theory focuses on probability theory and on operations research.

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

Learning from nature and utilizing microbial biodiversity to identify and characterize enzymes for degradation and upcycling of plastics and other polymeric materials.

What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

The genetic material of currently living Europeans is partly of Neandertal origin. Were our ancestors successful because they were hybridising and interacting with the local populations they encountered when migrating into new places? Reconstructing our evolutionary trajectory is key for rethinking…

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.

The mission of the Plant Sciences cluster is to contribute to the sustainable production of high-quality crops, flowers and high-value bio-based products, and to contribute to the maintenance and restoration of biodiversity in natural ecosystems. This is realised by generating fundamental knowledge…

Many researchers of the Faculty of Science are members of a research school related to their area of expertise. Research schools aim at collaboration of researchers from different faculties in the same university (interfaculty schools) or in different universities (interuniversity schools).

The group Clinical Neurodevelopmental Sciences has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

The Plant BioDynamics Lab (PBDL) is a laboratory dedicated to experiments designed to develop and validate quantitative mathematical models of dynamical processes in biology. The principal objective of developing these models is to make quantitative predictions about these processes.

On the 2nd of July, Axel Palmér successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Axel on this achievement!

Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Promotor: G.P. van Wezel

Promotor: Prof.dr. E.F. Smets, Co-promotores: Dr. B. Gravendeel, F. Pupulin

On the 1st of November, Andrew Wigman successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Andrew on this achievement!

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

Promotores: H.A. Udo De Haes, P.M. Brakefield

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

Where did species survive the cold cycles of the current Ice Age?

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Control of infectious diseases poses continuous challenges for human health.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

The Great Rift Valley in Africa is a real treasure trove for discovering early human fossils. The fossils found in this part of Africa have determined our view of human evolution. But was the Great Rift Valley really the place where evolution took place or just a place where fossils are well preserved…

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang