Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Bringing together scholars from Russia, the United States and Europe, this collection of essays is the first to explore the slippery phenomenon of post-Soviet nostalgia by studying it as a discursive practice serving a wide variety of ideological agendas.

The subject of motherhood is interwoven with themes of survival, power and identity. It is also at the heart of any consideration of women’s writing. Conversations of Motherhood sensitively charts common themes, intersecting experiences and related topics within the cultural specificities of South African…

Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

Do you enjoy a great story? In the Bachelor's programme Film and Literary Studies at Leiden University you study the stories behind the stories. Because what makes a novel fascinating or a horror movie frightening? Study film, literature and media from around the entire world and discover the differences…

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Large-scale computing infrastructure, such as supercomputers, cluster, and clouds, are already pervasive, most members of our society interact with them daily: social networks, government services, media streaming services--all systems heavily interfacing with the members of our society--are powered…

Reputation literature has provided crucial insights about the evolution of the US regulatory state. Daniel Carpenter’s influential account painstakingly demonstrates the relevance of reputation to bureaucratic ‘power’ and to early institutional state-building in the US context. We argue that adopting…

We investigate reaction systems, a novel computational model gleaned from the biochemical reactions taking place in living cells and information processing in nature.

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…

The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

The Prins Bernhard Cultuurfonds Award this year goes to musician, conductor and composer Reinbert de Leeuw, because of his great merit for contemporary music within The Netherlands and abroad.

Het bestuur van de Koninklijke Hollandsche Maatschappij der Wetenschappen maakt bekend dat de Dr. Elizabeth Schram-Mulley (ESM) Stichting met ingang van 2023 jaarlijks een prijs van € 10.000,- beschikbaar stelt ter bekroning van onderzoek met een bijzonder interdisciplinair karakter dat de grenzen tussen…

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

Development of Comprehensive and High-throughput metabolomics techniques and Clinical applications of (pharmaco)metabolomics

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

While acknowledging prominent legal-philosophical debates, this project proposes a radically different approach to provide insights into the concept of the rule of law.

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.

Political Islam is not new to the Middle East, but the appearance of ISIS has stretched the phenomenon to the extreme.

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…

The specialisation High-Tech Innovation is for MSc students in Sciences who are interested in interdisciplinary technologies and research related to /important for high technology industries, e.g. the semi-conductor industry or nano-fabrication.

Addressing Global Challenges through International Scientific Consortia

The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.

Research question

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

One of the most crucial aspects of our behaviour is our motivation to explore novel environments and interact with new people. This became painfully clear during the COVID-19 lockdowns, when many people suffered from lack of new experiences and real-life social interactions. The relevance of novelty…

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

How can we promote more durable solutions to protracted refugee situations and which roles can connectivity and mobility of displaced people play to improve protection and resilience?

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with the University of Havana.

To facilitate and accelerate a systemic change in society by creating a framework based on the current post-growth narratives, policies, and initiatives.

On Monday 15 February 2016 the annual Speckmann Prizes were granted at the Institute of Cultural Anthropology and Development Sociology. BA-studenten Laura Bakker, Kimberly Drijver and Martijn Kooijman were awarded for the best Fieldwork NL project; Rosi Aryal was honoured for having written the best…

The shift from response to recovery is now noticeable as the world moves past the paralyzing effects of the COVID-19 pandemic. This book explores responses to the pandemic by international, regional, and local institutions, multilateral action, and crisis prevention efforts at different levels of governance,…

Promotores: Prof.dr. M. Franx & Prof.dr. P.G. van Dokkum (Yale University)

The first book ever on information-theoretically secure multiparty computation

On 28 June, Jakob Tobing defended the thesis 'The essence of the 1999-2002 constitutional reform in Indonesia: remaking the Negara Hukum. A socio-legal study'. The doctoral research was supervised by Jan Michiel Otto and Adriaan Bedner.

Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

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Promotor: Prof.dr. E.J.J. Groenen