The thesis is part of a bigger project, the HEPGAME (High Energy Physics Game). The main objective for HEPGAME is the utilization of AI solutions, particularly by using MCTS for simplification of HEP calculations.

How to come to valid risk stratification of alcohol use disorder?

Jasper de Bruin, Guus Besuijen, Hans Siemons & Jeroen van Zoolingen (2012). De romeinse nederzetting bij het tegenwoordige Goedereede heeft waarschijnlijk een belangrijke functie gehad in de overslag en distributie van diverse goederen, waaronder keramiek en voedingsgewassen. De opgraving van deze nederzetting…

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

Medicines can work even if they have no active ingredient. The first international scientific conference on placebos will take place in Leiden from 2 to 4 April. Placebo researcher Andrea Evers, who is also chairing the conference, answers some pressing questions.

PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…

This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…

According to the LUMC, patients experience 30% fewer serious side effects when medication doses are tailored to their DNA.

This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

On 20 October 2021 Michael Ramsden defended the thesis 'The Role of the United Nations General Assembly in Advancing Accountability for Atrocity Crimes: Legal Powers and Effects'. The doctoral research was supervised by Prof. N.M. Blokker.

Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…

This article examines leadership encouragement and psychological safety as antecedents of prosocial rule-breaking (PSRB) behaviour.

More collaboration, combining data and asking the right questions. These are a few of the recommendations that policymakers and researchers formulated at the conference 'Data gedreven Beleidsontwikkeling' on 28 November 2017.

In their article; The Effects of Legal Measures to Empower Supervisory Directors: Evidence from a Financial Distress Perspective, Santen and De Bos discuss the relationship between the corporate governance structure of a company and its financial performance. Until now studies predominantly hypothesize…

First author Scott Waitukaitis and principal investigator Martin van Hecke have made the cover of Nature Physics with their publication on a newly discovered effect. The Elastic Leidenfrost effect explains why hydrogel balls jump around on a hot plate making high pitched sounds.

Promotor: A. Achúcarro, Co-promotor: A. Boyarsky

A coronavirus booster shot provides a better immune response against COVID-19 than a single vaccine dose. mRNA boosters are the most effective upon receiving Janssen. These are the results of a collaborative study between several organisations, including the Leiden University Medical Center (LUMC).…

Primary Objective: The primary aim of the proposed RCT is to evaluate whether LF-TLP in blended form as an indicated prevention for anxiety complaints is more (cost-) effective than TAU according to the NHG guideline Anxiety. We hypothesize that in comparison to TAU, LF-TLP will result in a significantly…

Rare-earth materials are prime candidates for storing quantum information, because the undesirable interaction with their environment is extremely weak. Consequently however, this lack of interaction implies a very small response to light, making it hard to read and write data. Leiden physicists have…

The latest research from the Leiden outdoor laboratory ‘Living Lab’ shows that the insecticide thiacloprid strongly influences even the most common and robust dragonfly species in the Netherlands. The study was published in the Journal of Applied Ecology.

Computers are capable of making incredibly accurate predictions on the basis of machine learning. In other words, these computers can learn without intervention once they have been pre-programmed by humans. At LIACS, we explore and push the borders of what a revolutionary new generation of algorithms…

Human measures to protect lions have an impact on the genetic health of populations. Leiden and Kenyan scientists discovered this by analysing the DNA of 171 Kenyan lions. ‘By fencing reserves, for example, the chance of inbreeding increases.’ With the knowledge and tools from the research, management…

A discovery made in Leiden helps not only to make natural gas from CO2 but also to store renewable energy. Research by Professor Marc Koper and PhD student Jing Shen shows how this process can be implemented in a cost-effective and controllable way. Nature Communications, 2 september 2015.

One of the objections to the Comprehensive Economic and Trade Agreement between Canada and Europe (Ceta) is that countries would be surrendering national sovereignty to multinationals which will obstruct effective climate policy. But compared to other trade agreements, CETA is an improvement.

Following the Mangold and Kücükdeveci case law of the CJEU, the horizontal direct effect of EU general principles and of provisions of the Charter of Fundamental Rights became a hotly debated issue.

Data science is of vital importance in preventing future outbreaks of viruses, Professor of Data Science Aske Plaat argues. Inaugural lecture entitled ‘Data Science and Ebola’ on 13 April.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

The aim of this study is to identify the side effects during treatment with methylphenidate and to investigate how children experience the use of the medication (such as Ritalin, Concerta and Medikinet).

Some examples of AI-research done at Leiden.

Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.

Patients on patient forums share all sorts of things about their illness: from side effects and advice to messages of support. PhD candidate Anne Dirkson uses artificial intelligence (AI) to retrieve this information. ‘Ninety per cent of the side effects weren’t officially registered.’

Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…

The Life in Custody (LIC) Study comprises a large-scale research project into prison climate and the quality of prison life in Dutch prisons.

Using N2 dissociation on Ru(0001) as a representative showcase (for catalysts employed in the Haber-Bosch process), we have shown for the first time that non-adiabatic effects can substantially reduce a molecule’s dissociation probability on a metal surface. These effects are currently completely unaccounted…

De inschrijvingen voor de Mmmonk school zijn geopend. Mmmonk School biedt een interdisciplinair praktijkgericht programma over middeleeuwse Vlaamse manuscripten. Experts geven een inleiding bij de belangrijkste concepten, methodes en vaardigheden uit hun discipline. De lessen zijn online, gratis, en…

Mmmonk en het Henri Pirenne Instituut voor Middeleeuwse Studies (UGent) organiseren eind 2024 de tweede editie van Mmmonk School: Lessen voor gevorderde beginners rond het middeleeuwse boek. Mmmonk School biedt een interdisciplinair praktijkgericht programma over middeleeuwse Vlaamse manuscripten. Experts…

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

Mark Klaassen presenter at the Reuniting Families: From Access to Integration event organized by the EU office of the Red Cross in Brussels.

By reforming agriculture in targeted areas, we can protect the Natura 2000 areas much more effectively. This is what Jan Willem Erisman of Leiden University and Ton Brouwer of Gispoint consultancy write in a new report. They have created a special, nitrogen map of the Netherlands that shows the areas…

Viktorija Kostadinova, from Macedonia and currently a second-year PhD student at the Leiden University Centre for Linguistics, has just returned after two and a half months at the University of Michigan: ‘It was a truly rewarding experience.’

How is interdisciplinary collaboration faring at Leiden University? And has disciplinarity been completely abandoned? I’d like to reflect on some concerns among colleagues and on our plans for the future.

The annual conference of the Global Transformations and Governance Challenges (GTGC) interdisciplinary research programme will take place in The Hague on 7-9 June. Why should you be there? ‘The problems in the world affect us all. This conference will be looking at planetary governance’, says programme…

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.