Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Questions of justice are not only the concern of legal professionals, politicians and activists, they also permeate culture at large. Literature, Cinema, Music and Artworks often revolve around questions about rights, justice and fairness, raising a wide range of issues, such as: how do we understand…

Developing a new way to measure marine biodiversity at high resolution, by listening to it.

The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.

Coral reefs throughout the world are under threat. After studying the reefs in Malaysia, Zarinah Waheed concluded that there is room for improvement in coral reef conservation. PhD defence 22 November.

PhD defence

How can we organise society so as to keep our planet habitable for us and for all other life forms around us? To answer this question, Leiden researchers collaborate across disciplines, from biology to data science, and from environmental economy to archaeology.

Speech Prosody 2024 includes three workshops.

Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…

A novel in vivo model system for studies on glucocorticoid resistance

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

From the largest numbers to the smallest molecules and from the oldest galaxies up to the latest algorithms, explore our standout discoveries and most inspiring collaborations from the past year!

Key publications of the Predictive Pharmacology group.

Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

Microbes influence and respond to other organisms. This theme explores the dynamic relationships within plant and animal microbiomes, and the immune responses that govern host defense. Using model systems such as zebrafish, insects, and plants, we investigate fundamental processes and engineer microbes…

The Faculty of Science

How can we make the information in handwritten historical research reports accessible and searchable? Data scientists at Leiden University are working with other universities on a method that will improve access to cultural heritage.

Do offshore windfarms affect the local biodiversity of the pelagic fish community and are fish deterred or attracted by sounds?

Our leadership model consists of four competences that align with our core values. Each leadership competence expresses two opposing qualities. The goal is not to prioritise one of these qualities over the other, but to find the right balance between them. Effective leadership starts with awareness…

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

The Creative Intelligence & Technology master's programme (previously Media Technology) at Leiden University focuses on creative exploration as well as the understanding of science and technology.

Within the Global Ethnography specialisation, you can develop your own research project or make use of the research opportunities offered by our staff members listed below.

Fleur Visser was awarded a Veni grant by the Netherlands Organisation for Scientific Research (NWO). She is one of seventeen promising young Leiden scientists, who get the opportunity to develop their own ideas over a period of three years. Veni-funding is part of NWO's Talent Scheme, concerning…

Source: Mediators Inflamm (2014)

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Observational, cognitive and physiological measurements in social contexts.

Fish climbing trees, storks taking care of their parents… Premodern textual and visual culture presents us with a fabulous bestiary that reveals ingenious and rich reflections on the animal kingdom.

From Complex Hunter-Gatherers to Early Urban Societies

We study expressions of emotion and social decision making across species.

Doctoral Thesis

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

This research network aims to promote cross-regional collaboration in the field of cultural history in early modern Asia at the intersections of visual, material, textual and aural culture.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Ruobin Han defended her thesis on 21 March 2017

A study on the utilisation of Iron Age rectangular structures and related depositional practices in the Low Countries

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

Consequences for sediment stability and seston trapping

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

How do mycobacteria subvert the defenses of host immune cells?

Can we link multiple components from herbal extracts with their biological activities?

Welcome to the Social Anxiety and Specific Phobia (SASP) Research Group!