Anthropogenic change is reshaping ecological systems, raising concerns about increasing transmission of infectious diseases. Among these, mosquito-borne diseases may be particularly sensitive to environmental change, as their transmission depends on vector populations.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

In this latest contribution to mimetic studies, Nidesh Lawtoo joins forces with leading international theorists of the posthuman to broaden the reach of the mimetic turn beyond human imitation.

Cities need to become greener, more biodiverse, and climate-resilient. However, many organisms that are vital for the functioning of urban green spaces and the wellbeing of urban citizens remain largely unknown.

Report on the Excavations of the National Museum of Antiquities Leiden in the Balikh Valley, Syria.

The Laboratory for Archaeozoological Studies is an advanced laboratory with advanced Leica stereomicroscopes and measuring instruments and an extensive reference collection which is used for research e.g. the identification of fossil remains. The collection is also used for teaching students the anatomy…

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Developing a new way to measure marine biodiversity at high resolution, by listening to it.

The handbook is a wide-ranging survey of a crucial period in prehistory during which many social, economic, and technological changes took place. Written by specialists in the field, the book provides coverage both of the themes that characterise the period, and of the specific developments that took…

This project aims to study the Aesopian fable from 1500 to the present day in its complex relationship between text, illustration and education, adopting a broad, transnational perspective.

Our education programmes span the entire spectrum of Animal Sciences, Evolution, Biodiversity and Conservation, Microbial Biotechnology and Plant Sciences.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

Investigating the relations between Tupi Indigenous Knowledge, Museum Collections and the Dutch Colonization of Brazil

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Investigating the making of knowledge in anthropology and natural history in colonial and postcolonial Indonesia.

Lecture

The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.

Speech Prosody 2024 includes three workshops.

How can we organise society so as to keep our planet habitable for us and for all other life forms around us? To answer this question, Leiden researchers collaborate across disciplines, from biology to data science, and from environmental economy to archaeology.

Coral reefs throughout the world are under threat. After studying the reefs in Malaysia, Zarinah Waheed concluded that there is room for improvement in coral reef conservation. PhD defence 22 November.

A novel in vivo model system for studies on glucocorticoid resistance

From the largest numbers to the smallest molecules and from the oldest galaxies up to the latest algorithms, explore our standout discoveries and most inspiring collaborations from the past year!

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

How can we make the information in handwritten historical research reports accessible and searchable? Data scientists at Leiden University are working with other universities on a method that will improve access to cultural heritage.

Key publications of the Predictive Pharmacology group.

Our leadership model consists of four competences that align with our core values. Each leadership competence expresses two opposing qualities. The goal is not to prioritise one of these qualities over the other, but to find the right balance between them. Effective leadership starts with awareness…

Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

The Faculty of Science

Microbes influence and respond to other organisms. This theme explores the dynamic relationships within plant and animal microbiomes, and the immune responses that govern host defense. Using model systems such as zebrafish, insects, and plants, we investigate fundamental processes and engineer microbes…

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

Do offshore windfarms affect the local biodiversity of the pelagic fish community and are fish deterred or attracted by sounds?

Within the Global Ethnography specialisation, you can develop your own research project or make use of the research opportunities offered by our staff members listed below.

What was the environmental impact of the industrial mining revolution that transformed southern Africa? Specifically, what was the impact of industrial mining when viewed from a more than human multi-species perspective?

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

The Creative Intelligence & Technology master's programme (previously Media Technology) at Leiden University focuses on creative exploration as well as the understanding of science and technology.

Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

This catalogue is the result of the EU_CUL project (2018-2021), which explores the use of cultural heritage in Europe for fostering academic teaching and social responsibility in higher education.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Patterns of paleomobility in the Caribbean were studied through an inter-disciplinary approach using a combination of archaeological, osteological, mortuary, and isotopic data.

Promotor: Prof.dr. M.K. Richardson