Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

What is the role of neuronal emotional reactivity in the intergenerational transmission of abuse?

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

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Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

How German Jews used photographs to document their experiences in the face of National Socialism.

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

The main goal of the THEOR CHEM group, headed by Prof. Geert-Jan Kroes, is to characterize, and to accurately predict the outcome of chemical reactions at gas-solid and liquid-solid interfaces. Here the solid surface is typically a metal or an ice surface. These goals are important to many areas in…

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

How does task context affect children’s word productions?

Mei-Wen Chen defended her thesis on 29 June 2016

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Can we use indigenous microbial rice communities to reduce methane production in agricultural settings?

Everyone knows smoking is unhealthy, but did you also know that smoking is not good for the environment? In parternship with UFB, we are organising a number of action days to pick up cigarette butts, hand out sustainable ashtrays and inform people about how they can smoke more sustainably!

The SAPPAO project aims to optimise the accuracy and reliability of predicting scheduled flight times. The full name of the project is 'A Systems Approach towards Data Mining and Prediction in Airlines Operations'.

The Leiden Science Young Talent Award is awarded yearly to a student who completed their bachelor’s degree with an excellent thesis.

The project will clarify that in the search for these new means the treatise On the sublime of ps.-Longinus played a crucial role. However, the project will also place the theatre performances in a broader social and political perspective. These public events and the theatre performances suggest that…

Muslims have lived in Eastern and South-Eastern Europe for centuries. Their arrival in Western Europe, the two Americas and Australia is however relatively recent. Studying how Muslims relate to their Western environment (and vice versa) and the mutual influences of Western and Islamic philosophies…

Research at the THEOR group is comprised of the following research themes:

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

Research lines within the Pharmacy group:

Both Leon Jacobse and Thom Hersbach from Marc Koper's research group obtained their PhDs cum laude. They both investigated changes on the surface of a platinum electrode. Jacobse studied this at a positive voltage, Hersbach at a negative voltage. Platinum has the potential to convert renewable energy…

From Incident to Precedent

How does CO adsorption on gold promote its own oxidation and the oxidation of other organic molecules?

In a full lecture hall C1 the Faculty of Science started off the new academic year on Tuesday 5 September. The theme of the meeting was, just as it had been at the university's opening the day before, sustainability.

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

Electrochemist Marc Koper has been awarded an ERC Advanced Grant of 2.5 million euros for research into chemical reactions driven by electrodes and electricity. He hopes that new insights will make it into the textbooks and help design green processes, such as making fuel from greenhouse gas.

Research of the Leiden Institute of Chemistry into the development of a sustainable fuel cell has accidentally resulted in an exceptionally efficient catalyst for the production of hydrogen peroxide. The catalyst, discovered by Dennis Hetterscheid and PhD candidate Michiel Langerman, may lead to a more…

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How are the building blocks of life formed?

This project compares and contrasts how and why several Turkish and Iranian women were compelled to participate in leftist guerilla movements in the 1960s and 1970s.

Why does the past elicit this intense activity in the present? What does the past mean for the present, and what does it do to it? A WAR OF WORDS will engage this complex of Chinese claims to Manchu-Korean ancient history, South Korean reactions, public discourse and cultural expression in both states,…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

How can the combination of sound composition, astrochemistry, and epistemological analysis provide new and unexpected insights into interstellar chemical reactivity?

We would like to present to you a simple guidebook about living a sustainable life as a student in the cities of Leiden and The Hague. Whether you are a first-year student still trying to find your way around or already doing your masters – students wanting to explore more sustainable options and save…

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Objects, Appropriation and Cultural Change

Theorists have recently made substantial progress in simulating reactive molecule-metal surface scattering but still face major challenges. The grand challenge is to develop an approach that enables accurate predictive calculations of reactions involving electronically excited states with potential…

Too big to jail?

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent