Promotor: Prof.dr. J. Kuiper

Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

Promotor: R. Gill, Co-promotor: P. Massart

In this thesis we study bistable reaction-diffusion equations on lattice domains.

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with Boston Children’s Hospital in the USA.

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

The transition from single cells to multicellular organisms was a key step in evolution. Researchers from Leiden and Amsterdam developed a mathematical model that explains how this transition may have come about. They suspect cooperating cells may correct each other’s mistakes. Publication in eLife…

Publication by: Amanda Foks, Gijs van Puijvelde, Jolien Wolbert, Mara Kröner, Vanessa Frodermann, Thomas van der Heijden, Peter van Santbrink, Louis Boon, Ilze Bot and Johan Kuiper. Cardiovascular Research. 2016;111(3):252-261.

Leiden and Austrian researchers have succeeded in further uncovering how a plant cell passes on the growth hormone auxin in a directional manner to the next cell. Three proteins that cling together in a bunch appear to be essential for this important transport process. ‘This discovery solves a crucial…

Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…

Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.

How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.

A more efficient solar panel sounds great. But what if these new panels consume more toxic materials, or their production consumes a lot of energy? Leiden environmental scientists, together with colleagues from the Fraunhofer ISE, address this multifaceted question in a new publication in the prestigious…

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…

Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotores: W. Jiskoot, F. Ossendorp

Can furan-based resisn be degraded by microbial enzymes in combination with mild pre-treatment?

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.

Archive of old software and data

Learning from nature and utilizing microbial biodiversity to identify and characterize enzymes for degradation and upcycling of plastics and other polymeric materials.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Heart failure is a major health care problem with high mortality.

The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market.

Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…

We consider the propagation of electrical signals through nerve fibres.

Behavioral and neural mechanisms underlying risky decision-making in adolescents