We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Promotor: M.A.G.J. Orrit

In the contemporary myriad of definitions and approaches of landscape, the starting points and limits of the concept of landscape biography are being explored, but also tested in this thesis. What exactly is a landscape biography? What does it constitute of? Is landscape biography just a narration of…

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

This research note argues that the “lone wolf” typology should be fundamentally reconsidered.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

It is with great pleasure that we present to you the second volume of Inter-Section, published in 2017.

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

Andrew DJ Shield (History) and Ann Marie Wilson (Leiden University College) have been awarded a seed grant for their project, “Transnational Gay/Lesbian Activism since the 1960s.” Granted: €3000.

ILS organizes monthly Lunch Seminars in which all researchers from Leiden Law School can present their research. The idea is to share in an open and accessible way what researchers from other research programs and institutes are working on. During a seminar, two or three speakers will present their…

The Psychology Research Seminars are organised by and for institute staff. They offer an opportunity to share knowledge, gain new insights, and meet colleagues from various disciplines.

The state should prepare 'lifers' better for returning to society, for example by giving them some control over their own lives. This is the finding of Marieke Liem in her book 'After Life Imprisonment', published on 19 August.

The main purpose of DNAmarkerpoint is to better understand the ecology, evolution and biodiversity through the study of ancient- and modern DNA.

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Knowledge and culture subproject 1:

In this thesis we use state-of-the-art observations and simulations to provide the best constraints to date on the HVS ejection rate and constraints on the stellar content and dynamics at the GC, including the progenitor binary populations and their star formation history.

Intelligent machines are going to make ethical decisions too. Should a self-driving car be allowed to slam into pedestrians to save its passengers from a head-on collision? Should a negotiation app be able to detect stress in your opponent’s voice? And who makes these decisions: the user, the system’s…

If researchers make their data FAIR, computers can link large quantities of data and identify patterns, thus greatly accelerating the process of arriving at new insights. In Leiden, the birthplace of ‘FAIR data’, Professor Barend Mons explains the meaning of this term.

We explore the possibilities to combine magnetic resonance techniques with atomic force microscopy together in a single microscope: the MRI-AFM, also called Magnetic Resonance Force Microscopy (MRFM).

At Leiden Observatory, researchers investigate the origin of stars and their planetary systems. They detect and characterize planets around other stars (exoplanets). They study how stars and planets form. And they follow molecules from interstellar clouds to nascent planet systems. This way they address…

If an algorithm has to learn to understand language, simply having a lot of data doesn’t help much. Like us, a computer has to learn the language in interaction with others. Tessa Verhoef is fascinated by how this interaction works.

What workflow of non-destructive techniques provides accurate, valuable data to improve our understanding of Caribbean archaeological landscapes? How were Amerindian settlements configured?

Browse the latest articles and issues of Inter-Section.

MRFM combines the principles of magnetic resonance and atomic force microscopy.

This project aims to improve understanding of, and responses to, the phenomenon of lone actors through analysis of comprehensive data on cases from across Europe.

Coordination chemistry is the chemistry of metal atoms

As a student of the Master's in Comparative Criminal Justice you develop academic, theoretical and research insight in all aspects of crime control. Student actively work on current, concrete problems and are challenged to independently find solutions. Students not only learn about the organization…

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

Commentators and scholars view both social media and cities as sites of fragmentation. Since both urban dwellers and social media users tend to form assortative social ties, so the reasoning goes, identity-based divisions are fortified and polarization is exacerbated in digital and urban spaces.

Health Data Science Leiden University

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

Plastics have become an integral part of modern society due to their versatility and durability.

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

Promotor: V. Vitelli, Co-promotor: J. Paulose

The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.

The mechanism of the electrochemical reduction of dioxygen by a mononuclear pyridylalkylamine copper complex was investigated (see picture). It was shown that in neutral aqueous solution dioxygen undergoes stepwise reduction, wherein hydrogen peroxide plays a key role. The rate constants determined…

Our cantilevers have a low intrinsic damping rate: this enables us to measure with low noise, since damping is proportionate to noise. However, when the magnet is close to the surface of a sample we want to study, we measure a much higher effective damping rate. This is caused by magnetic interaction…

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

High resolution altitude data created by airborne LiDAR allow the investigation of large areas and often inaccessible tracts of land and has the potential to reveal undiscovered archaeological heritage.

This research delves into a region of space known as the interstellar medium (ISM), which is essentially the area between the stars filled with gas and dust.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.