Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Retrospection over the last 40 years the most important changes in care and research, where transparency accountability and guidelines became leading. On Huntington’s disease and cerebrovascular disorders the most important changes are illustrated.

The field of science communication is very broad. Below is a list of organisations where SCS students can fulfill internships or where alumni have found jobs.

CT scanning of skeletal remains can tell us about how strong or weak a persons bones were and we can relate that back to diet, activity, and reproductive factors.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

We are dedicated to creating a thriving open knowledge community. This challenges us to innovate and take action. Therefore, Leiden University commits to:

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The research connected to this topic is related to Work and health.

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This focus area centres on promoting health and stimulating the physical, mental and social resilience of citizens.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

How are the epidermal lipid pathways involved in health and disease.

PhD defence

PhD defence

Clothes by big Western brands that are on sale in Dutch shops are sometimes made by North Korean workers. The Dutch state is co-financer of a motorway that is being built in Pakistan by exploited workers. These are the conclusions of a report published by the LeidenAsiaCentre on 2 April.

How effective is eye movement desensitization and reprocessing therapy in targeting epilepsy-related anxiety?

This project has two main aims: I. Determine when novelty promotes fear extinction. II. Discover the neurobiological mechanisms underlying these effects.

Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

Do you want to make an impact in healthcare?

The Psychology Research Seminars are organised by and for institute staff. They offer an opportunity to share knowledge, gain new insights, and meet colleagues from various disciplines.

Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…

The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

The LACDR represents the core of bio-pharmaceutical research at Leiden University, and we interact closely with our partners:

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

IT lawyer Eduard Fosch Villaronga wants to promote diversity and inclusiveness in AI research. And that's really important, because he has observed how artificial intelligence - from Twitter to walking robots - is prejudice in terms of race, gender and sexual orientation.

An overview of the research at the Biologics Formulation group

At Leiden University, researchers from all disciplines work together to find answers and design innovations in the field of artificial intelligence.

Social anxiety runs in families, but the neurobiology underlying this genetic vulnerability is until now largely unknown. The unique Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) aims to broaden our knowledge with respect to this genetic susceptibility.

The Faculty of Science

This project seeks to integrate scientific research and practical knowledge in the study of the mechanisms that make dialogue an effective tool for communication, teaching, and thinking.

In this research line, the role pharmacological agents and neurochemcial processes play in behavior and cognition is examined with a particular focus on pain, placebo and nocebo effects and intensive care treatments.

Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?

Positive expectations can influence sensations of itch and evoke placebo effects, whereas negative expectations can trigger nocebo effects in itch. There is evidence that placebo effects can occur even when people know that they are taking a placebo. Little is known about how these so-called open-label…

By carrying out fundamental research and providing excellent education, universities become a breeding ground for innovation and entrepreneurship.

The STAP study examines the cost-effectiveness of Written Exposure Therapy (WET) for post-traumatic stress disorder (PTSD) symptoms in primary care settings.

The Biomedical Sciences Master programme in Leiden will help to deepen and broaden your understanding of human health and disease. We provide you with a challenging and flexible programme in a personalized environment.

The research master's specialisation Clinical and Health Psychology consists of five main parts: the general courses, the track-specific courses, the elective courses, a research internship and a thesis.

The Keuzegids is an independent consumer guide that compares all (master’s) programmes in the Netherlands. Students evaluate the programmes based on content, atmosphere, lecturers, assessment, and career preparation.

The majority of scientists, from archaeologists through to zoologists, collect huge volumes of data. Their massive databases contain large amounts of information which is difficult for humans to filter. With a solid grounding in statistics, we can develop algorithms for analysing and identifying patterns…

A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.

Promotores: J. Jonkers, K.E. de Visser

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: J. Kuiper

Here you can find products and research tools developed by the Navigation Lab Leiden

Argumentation and rhetorics is the study of how we convince people verbally. In other words, what do people say and how do they say it?

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.