Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…

FSW Professor Jan Dirk Blom has written a book on Alice in Wonderland syndrome. This is the first scientific book on this rare disorder, which was first described in 1955 by the British psychiatrist John Todd. Todd was inspired by the famous book by Lewis Carroll, in which Alice experiences all kinds…

If a new method has been developed to recognize and treat a (neuro-)psychological disorder or related behavioral factors, it cannot yet be used directly in clinical practice. First, the method should be evaluated, preferably in randomized controlled trials.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Alain studies Public Administration and is politically active. He talks about why it is important for young people to be politically active and vote.

From September 1 onwards, Jonatan Wirix-Speetjens is the new assessor of the Faculty of Humanities. He takes over the baton of former assessor Olivier Fajgenblat. To get to know him a bit better, he introduces himself in this video.

Imagine how much time, money and discomfort it would save: a personalised treatment for each individual patient. Precision medicine like this is coming ever closer, thanks in part to Elise Dusseldorp’s algorithms. They retrieve a wealth of information from research data.

A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.

LUMC researchers are looking for factors that point to illness at an early stage.

Cognitive decline (amongst other problems with attention, concentration, memory) is a common symptom in patients with a variety of brain disorders and has been related to healthy ageing as well. People suffering from cognitive deficits are often significantly hampered in their day-to-day functioning…

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…

Joost Batenburg is a mathematician and computer scientist who works to build bridges to other disciplines. He hopes to bring intelligent software to fields where it can make a difference. Conversely, he also seeks connections to the disciplines that are needed to make AI a success.

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

LUMC researchers are looking for factors that point to illness at an early stage.

While many healthcare professionals indicate that they frequently use placebo effects and their mechanisms, there is little formal training on how to deal with placebo and nocebo effects in clinical practice. This project aims to address this gap between scientific knowledge on placebo and nocebo effects…

The master's specialisation Clinical Neuropsychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.

Depression in young people is often treated as an individual problem. But looking only at the child means that an important part of the story is missed, says PhD candidate Myrthe Veenman: ‘Parents can make a difference.'

Our research programme collaborates with all kinds of partners to achieve our goal: bringing scientific discoveries to the clinic as soon as possible.

The focus of health care is rapidly changing. The need for maximum gains with minimal input requires tailored health care strategies and an ever more explicit evaluation of health benefits for the patient.

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

Text Mining and Retrieval Leiden (TMRL) focusses on text mining and retrieval problems in complex domains.

The impact of the phenotypic plasticity of P. aeruginosa and the distinct CF lung microenvironments on antibiotic drug effects and resistance remains poorly understood.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

This research line is part of the living lab of the University’s Population Health interdisciplinary program, located at the LUMC Campus The Hague, where the Leiden University Medical Center collaborates with the Faculty of Governance and Global Affairs and the Faculty of Social and Behavioral Sciences…

Primary Objective: The primary aim of the proposed RCT is to evaluate whether LF-TLP in blended form as an indicated prevention for anxiety complaints is more (cost-) effective than TAU according to the NHG guideline Anxiety. We hypothesize that in comparison to TAU, LF-TLP will result in a significantly…

The goal of pre-clinical development is to bridge the transition from lead compounds to clinical candidates by comprehensively characterizing safety, efficacy, and pharmacological properties. Once a lead compound demonstrates promising activity in disease models, it enters pre-clinical development where…

Current research at the Skin Barrier and Vaccination group.

The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…

Faculty Lecture

Investigating neurobiological endophenotypes of Social Anxiety Disorder

In 2019 Leiden University was 444 years old. This special birthday called for a special celebration. We celebrated this milestone with the residents of Leiden and The Hague. In, with and for these two cities.

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

The key question addressed in this family study is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable and can thus be found in family members of SAD patients as well. Determination of heritability of these deficiencies is essential for endophenotyping.…

Music can affect how we feel, think, and behave. But how do we learn about the specifics of people's responses to music so that we can apply this to health and well-being? By looking at characteristics of the music, as well as the differences between listeners, we hope to better understand as well as…

Seven large reproductions of works by Rembrandt on seven University buildings in the centre of Leiden reveal the relationship between the painter and the University. Rembrandt van Rijn enrolled in the University in 1620 and painted the portraits of various alumni of the University. The exhibition runs…

To investigate the effectiveness of an online self-help programme for people with HIV and depressive symptoms.

One of the most crucial aspects of our behaviour is our motivation to explore novel environments and interact with new people. This became painfully clear during the COVID-19 lockdowns, when many people suffered from lack of new experiences and real-life social interactions. The relevance of novelty…

Exploring the synergy of light therapy and exposure psychotherapy to enhance PTSD treatment outcomes.

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We are moreover strongly involved in the Master specialisation of Pharmacy at Leiden University. We work on clinical problems that require further mechanistic understanding and…

PhD defence

NWO-ALW has funded the project Climate impact on human evolution: age calibration of the ICDP Hominin Sites and Paleolakes Drilling Project (HSPDP), led by PIs Cor Langereis and Guillaume Dupont-Nivet (Utrecht University).

Inviting members of the public to help monitor wildlife, photograph plants or conduct samplings. These are some of the many examples of Citizen Science. It is increasingly recognized as effective and impactful for collecting data, but also for engaging the public in scientific research. In Nature reviews…

Governments are increasingly cracking down on tech companies like X, Telegram and Clearview that flout the law, with a fine, ban or criminal prosecution. In practice, however, this has little effect. A tougher stance is needed, argues Bart Custers, Professor of Law and Data Science at eLaw – Center…

Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Retrospection over the last 40 years the most important changes in care and research, where transparency accountability and guidelines became leading. On Huntington’s disease and cerebrovascular disorders the most important changes are illustrated.

The field of science communication is very broad. Below is a list of organisations where SCS students can fulfill internships or where alumni have found jobs.

CT scanning of skeletal remains can tell us about how strong or weak a persons bones were and we can relate that back to diet, activity, and reproductive factors.