The 2004 Indian Ocean tsunami caused immense destruction and over 170,000 deaths in the Indonesian province of Aceh. The disaster spurred large-scale social and political changes in Aceh, including the intensified implementation of shari‘a law and an end to the long separatist conflict. After the Tsunami…

What is the role of the noradrenergic system in human cognition?

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.

The research connected to this topic is related to E-health.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

What kind of attentional focus can enhance learning and performance for musicians?

On 21 February 2019, Ruben Zandvliet defended his thesis 'Trade, Investment and Labour: Interactions in International Law'. The doctoral research was supervised by Prof. dr. N.J. Schrijver.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

The secretariat is part of the Institute for the Interdisciplinary Study of the Law, part of Leiden Law School. The Institute Coordinator is in charge of the secretariat and the Institute's Academic Director is ultimately responsible for the secretariat. The secretariat provides administrative support…

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Cyber security is one of the critical challenges in our inter-connected world. Organizations are being constantly targeted by adversaries. Various critical systems become exposed on the Internet. Users can find that their data has been stolen from a company that they were not even aware of.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

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This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

How do humans control their thoughts and actions, and what can high-field brain scanning reveal about the underlying processes?

Lecture

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Effective policy-making requires understanding what truly causes a problem. Only then can policymakers develop targeted interventions that achieve desired outcomes.

What is ‘teaching excellence’ in Higher Education? Which different teaching excellence training, promotion and reward schemes exist across Europe? How can a common European teaching scheme look like? The e-NOTE project led by Leiden University with the participation of Charles University and other partners…

PhD defence

PhD defence

PhD defence

PhD defence

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

PhD defence

Which features characterize speakers’ voices, and how are these features determined by what a speaker is saying?

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.