Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

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How do humans control their thoughts and actions, and what can high-field brain scanning reveal about the underlying processes?

This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Lecture

What if you could watch a CT scan live, instead of analysing the images afterwards? If it is up to the Leiden mathematician Jan-Willem Buurlage, that will soon be a reality. He is developing methods to make the algorithms behind 3D scans faster. Quite a challenge: ‘Just like mathematicians, computers…

PhD defence

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

Which features characterize speakers’ voices, and how are these features determined by what a speaker is saying?

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

The aim of our research program is to better understand the etiology and course of mood, anxiety and stress-related disorders, such as depression and posttraumatic stress disorder (PTSD). We investigate both the transdiagnostic mechanisms underlying these disorders and work on improving the treatments…

This thesis surveys the intersection of computed tomography (CT) and machine learning (ML), treating CT as an ill-posed inverse problem shaped by object properties, imaging physics, and data limitations.

In this article, Marco Cinelli, assistant professor at Leiden University College The Hague, examines proper and improper uses of Multiple Criteria Decision Analysis (MCDA) methods in energy systems analysis.

On 21 November 2018, Lieke Kools defended her thesis 'Essays on wealth, health, and data collection'. The doctoral research was supervised by Prof. dr. K.P. Goudswaard en Prof. dr. C.L.J. Caminada.

The master’s specialisation Biodiversity and Sustainability at Leiden University provides students with a much better understanding of the biological processes which are essential for creating a sustainable society.

Research in Bio-Pharmaceutical Sciences consists of 120 European Credit Transfer System (EC) points.

In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…

While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

A liveable planet. More biodiversity. And resources which are being managed wisely. At the CML, we want to make an impact with our research and education. On this website you can read what we do to achieve that.

What are the critical elements in sonic materialization of fixed media electroacoustic music and how can these parameters be classified? How would interpretation be defined in performing fixed media music? What are the creative and new ways of presenting fixed media music by incorporating all the presentation…

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

The Biomedical Metabolomics Facility Leiden (BMFL) is the core metabolomics facility of Leiden University and the Metabolomics and Analytics Centre (MAC). We offer a highly structured environment for advanced MS-based metabolomics studies and build on fully validated, state-of-the-art assays that each…

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

igraph development focused on improving the most-used interfaces, which are Python, R, and Mathematica. Additionally, the developers aim to make the library and the interfaces easier to maintain, focusing on long-term sustainability. This ensures that igraph continues to be a useful tool for network…

Here we share findings into the effectiveness of the Designing Your Life education at Leiden University. Our study indicates that DYL education has a positive effect on students’ confidence and competencies.

The Centre for Indigenous America Studies (CIAS) at Leiden University is designed to coordinate and promote the teaching and research of Indigenous languages, literatures, cultures and cultural heritage.

Promotor: M.A.G.J. Orrit

This dissertation aims at enhancing our knowledge of whether a CI provides sufficient access to auditory speech input to acquire verbal morphology by comparing outcomes of CI children to those of their normal hearing peers and to those of children with specific language impaired (SLI).

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

The data-driven economy allows for the collection and processing of large amounts of data. Such data can be used to optimize profits by (dynamically) differentiating prices for different consumers.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

The presents thesis investigates the extent to which Chinese, Dutch and American speakers of English are mutually intelligible. Intelligibility of vowels, simplex consonants and consonant clusters was tested in meaningless sound sequences, as well as in words in meaningless and meaningful short sent…

This PhD project investigates how grammatical features and lexical elaboration in Fulfulde Juguureere reflect aspects of cattle culture.

The more we learn about a (neuro-)psychological or physical disorder and the related behavioral factors, the better we can not only identify them, but also treat them. It is therefore important that recent insights about (neuro-)psychological problems and related behavioral factors are incorporated…

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

This project analyses the democratic consequences of increasing decentralization and regionalization in European countries. Through an original approach that foregrounds informal political dynamics, it studies the functioning of democracy in subnational units, and investigates the effects of ever more…

Can furan-based resisn be degraded by microbial enzymes in combination with mild pre-treatment?

Supervisor: Indira Nederpelt