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Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Promotie

Laatste technologische ontwikkelingen op het gebied van datamining en profilering.

In this article, Eamon Aloyo argues that university supervisors should not use student evaluations of teachers as a measure of teaching effectiveness.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Promotie

Promotie

Formele gelijkheid vormt sinds lange tijd het hart van EU en internationaal non-discriminatierecht. Daarnaast is materiële gelijkheid door de jaren heen een wettelijke norm geworden, onder meer door middel van de ontwikkeling van de concepten van indirecte discriminatie en doeltreffende aanpassingen…

Op 17 oktober 2017 vond in het Brusselse kantoor van de University of Warwick een internationale conferentie plaats in het kader van het onderzoeksproject

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Promotor: R. Gill, Co-promotor: P. Massart

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Op 19 april 2018 organiseerde de Universiteit van Wenen een internationale conferentie over het onderwerp openbare instanties voor de bevordering van gelijke behandeling.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Dr. Moritz Jesse, universitair hoofddocent bij het Europa Instituut, presenteerde zijn paper Building Bridges or Erecting Walls? – The Application of Equal Treatment and Non-Discrimination in Europe ‘ tijdens de jaarlijkse bijeenkomst van de Vereniging voor Recht en Samenleving.

Moritz Jesse has been awarded a Jean Monnet Chair by the European Commission. In his MIND-EU Project he will focus on a coherent way to teach Migration, Integration, and Non-Discrimination at Leiden Law School at bachelor and master level.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

In het curriculum van het eerste semester volgen studenten voornamelijk de gezamenlijke GMD-cursussen, samen met medestudenten uit de andere tracks van het GMD-masterprogramma. Het tweede semester richt zich op de juridische vakken en het schrijven van de LL.M.-scriptie.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Promotor: Prof.dr. J. Kuiper

Op 29 en 30 juni 2018 vond in Leicester (Verenigd Koninkrijk) een boekworkshop plaats over algemene beginselen.

Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

Dr. Moritz Jesse, Europa Instituut van de Leidse rechtenfaculteit, heeft een Jean Monnet-leerstoel gekregen. Vanaf november 2023 zal Moritz cursussen op bachelor- en masterniveau geven als onderdeel van zijn project ‘Migration, Integration, Non-Discrimination in the EU’ [MIND-EU]. Vanaf volgend jaar…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Nederland heeft afgelopen week de nationale terrorismelijst uitgebreid: tien Nederlanders zijn aan deze lijst toegevoegd. Dit heeft onder andere gevolgen voor hun financiële middelen, maar is dit middel wel effectief? En wat als je onterecht op deze lijst terecht komt? De NOS sprak hierover met Jelle…

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

In Nederland zijn er ongeveer 36.000 zeer makkelijk lerende kinderen in de basisschoolleeftijd. Hoe zorg je er als school voor dat zij niet in de knel komen?

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.