The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

feestbundel voor de Britse demotisant Cary J. Martin (UC Londen)

Linde Desmaele onderzoekt de rol van Amerikaanse tactische kernwapens in Europa. Zij stelt dat deze wapens voornamelijk dienen als instrumenten voor bondgenootschapsbeheer.

Why do sexual violence policies still fail to systematically address men and masculinities, when the need for cultural change among men has been central in public debates since #MeToo?

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

Promotores: J. Jonkers, K.E. de Visser

Promotores: F.H. van Lunteren, F.P. Israel

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

Promotor: Prof.dr. G.P. van Wezel

Bij de Onderzoeksgroep Geweld en Geweldpreventie (Violence and Violence Prevention) wordt onderzoek gedaan naar de complexiteit van hedendaags geweld, de uiteenlopende verschijningsvormen ervan en strategieën voor preventie.

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

Promotor: J. Schaye

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Promotor: Prof.dr. C.W.J. Beenakker

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Heart failure is a major health care problem with high mortality.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

To study how planetary systems come into existence we study much younger systems still in formation.

Promotor: Prof.dr. J. Kuiper

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

We present an extensive study of methods for exactly solving stochastic constraint (optimisation) problems (SCPs) in network analysis. These problems are prevalent in science, governance and industry.

I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

Promotor: Prof.dr.ir. E. Deprettere

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Promotor: S.M. Verduyn Lunel

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

The radio sky harbours both galactic and extragalactic sources of arcminute- to degree-scale emission of various physical origins. To discover extragalactic diffuse emission in the Cosmic Web beyond galaxy clusters, one must image low–surface brightness structures amidst a sea of brighter compact fore-…

Promotor: P.D. Grünwald

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…