The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Promotie

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotores: T.H. Oosterkamp, N. de Jonge

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Patients share valuable advice and experiences with their peers in online patient discussion groups.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Promotor: Prof.dr. J. Kuiper

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Promotie

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Promotie

Boyd Leupen heeft de MSc Thesis Prize 2015 gewonnen. Met ‘Refuting asymmetrical Kantianism: On the moral standing of animals’ rondt Leupen zijn Masteropleiding Political Science af en levert hij een waardevolle bijdrage aan de politieke filosofie. Volgens de jury onderscheidde Leupens masterscriptie…

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

Dimiter Toshkov, universitair docent bij het instituut Bestuurskunde, is een van de twee prijwinnaars van de Haldane Prize.

De Leidse politicoloog Daniela Stockmann heeft de Goldsmith Book Prize 2015 gekregen voor het beste academische boek op het gebied van media, politiek en overheidsbeleid. De jury roemde het als 'een van de belangrijkste werken die ooit met de Goldsmith Award zijn bekroond.'

Oud-biologiestudent Benjamin van Soldt heeft de Arenberg-Coimbra Group Prize for Erasmus Students 2015 gewonnen. Die gaat naar de Erasmusstudent van een van de Coimbra-universiteiten die wetenschappelijk gezien het meest uit de Erasmus-uitwisseling heeft gehaald.

Milan Allan heeft de Bryan R. Coles Prize gewonnen op de International Conference on Strongly Correlated Electron Systems (SCES) in Praag.

De European Physical Society heeft de prestigieuze Edison Volta Prize toegekend aan Leids natuurkundige Michel Orrit. De prijs wordt elke twee jaar uitgereikt aan een individu of groep van maximaal 3 wetenschappers ter erkenning van een buitengewone prestatie in natuurkundig onderzoek.

Op 6 september 2021 heeft dr. Vestert Borger, universitair docent Europees recht, de Best Book Prize ontvangen van de University Association for Contemporary European Studies (UACES). Borger ontving de prijs voor zijn boek The Currency of Solidarity: Constitutional Transformation during the Euro Cri…

Met de publicatie “Think tanks and strategic policy-making: the contribution of think tanks to policy advisory systems” heeft Bert Fraussen, als universitair docent verbonden aan het Instituut Bestuurskunde, de Harold D. Lasswell Prize gewonnen.

De drie studenten namen aan de competitie deel met een businessplan dat ze ontwikkelden tijdens een cursus ondernemen. Ze ontwierpen een succesvol en goedkoop systeem om slachtoffers van sneeuwlawines onder de sneeuw te lokaliseren. De huidige navigatietechniek voor satellieten biedt de benodigde accuratesse…

PhD researcher David Font Vivanco, together with Ester van der Voet, Reinout Heijungs and Renée Kemp (Maastricht University) won the Graedel Prize 2014 for best paper published by a junior author in the Journal of Industrial Ecology.

Leidse Biologiestudent Lukas Kiefer heeft de Unilever Research Prize 2018 gewonnen voor zijn onderzoek naar de efficiënte productie van een nieuw antibioticum. Kiefer: 'Ik wil biologische medicijnen beschikbaar maken voor mensen in nood.'

Pas 35 jaar en nu al leider van een onderzoeksgroep, op weg naar vaste aanstelling. En: talloze papers, subsidies en beurzen op zijn naam. Leidse natuurkundige Jordi Tura i Brugués ontvangt vandaag de Young Scientist Prize voor zijn bijzondere bijdragen aan quantum-onderzoek.

De Environmental Sciences Research Prize 2012 is uitgereikt aan CML onderzoeker David Font Vivanco door de Environmental Scientists Association van Catalonië.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.