Om in te loggen met uw ULCN-account heeft u Multi-Factor Authenticatie (MFA) nodig. Dat wil zeggen dat u, behalve met uw gebruikersnaam en wachtwoord, ook op een andere manier bevestigt dat u het bent.

CML-IA is a database that contains characterisation factors for life cycle impact assessment (LCIA) and is easily read by the CMLCA software program.

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Promotor: Prof.dr. J.P. Abrahams

Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Factors affecting galanthamine production in Narcissus

This thesis investigates how non-genetic factors, such as inflammation and concomitant medication, impact hepatic drug metabolism and subsequent drug metabolizing phenotype predictions.

Promotor: J.M. Memelink

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Welke politieke factoren beïnvloeden de snelheid of duur van de wetgevingsbesluitvorming in de EU?

This paper describes the development process of voting behavior in Chile; particularly the relationship between the class voting theory and the theory of cultural post-materialist vote is investigated. This research deals with Chile as a case study, a developing country with a relatively stable democracy…

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

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Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

De auteurs presenteren een benadering voor het achterhalen van de voorkeuren van de bevolking voor gebruik in de optionele wegingstap in de Levenscyclusanalyse (LCA).

In dit artikel stelt Tom Buitelaar een systematisch kader voor om het effect van individuele kenmerken van vredeshandhavers op het gedrag van grondpersoneel bij VN-vredesoperaties te analyseren.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Up to 45% of patients with Parkinson's disease experience impulse control disorders, characterised by a loss of voluntary control over impulses, drives or temptations. This study aimed to investigate whether previously identified genetic and psychiatric risk factors interact towards the development…

Catharanthus roseus (Madagascar periwinkle) produces valuable monoterpenoid indole alkaloids (MIAs) such as vincristine and vinblastine, crucial for cancer treatment.

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

Status plaatsingsproces

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

Leidse onderzoekers ontdekten dat het eiwit annexine A1 een belangrijke rol speelt in uitzaaiing van borstkanker. Het reguleert de plasticiteit van cellen waardoor tumorcellen beweeglijk worden en kunnen uitzaaien. Dinsdag 23 maart publiceren ze hun resultaten in PNAS Online Early Edition.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

In de LDE Honours Class ‘Living (World) Heritage Cities’ leren studenten uit Delft, Rotterdam en Leiden op welke manier werelderfgoed beschermd wordt en hoe een erfgoedstad ook in de toekomst leefbaar blijft. Volgens initiatiefnemer van de Class Mara de Groot heeft het namelijk zeker niet alleen maar…

Promotores: G.A. Persoon, H.H. de Iongh

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

Van waterzuiveringsinstallaties tot een lekkere warme douche, de CO2-uitstoot ten gevolge van het watergebruik in de VS staat gelijk aan dat van 50 miljoen auto’s die een jaar lang rondrijden. In The Washington Post raadpleegt journalist Tik Root verschillende experts om te leren over manieren om ons…

De kansen voor Rutte om secretaris-generaal van de NAVO te worden lijken alleen maar toe te nemen. Zeker nu de VS en de meeste westerse landen steun hebben betuigd. Wim Voermans, hoogleraar Staats- en bestuursrecht, spreekt over wie op deze positie te benoemen in WNL Op Zondag.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

CONSENT (Consumer sentiment regarding privacy on user generated content services in the digital economy) is a research project funded by the European Union under the 7th Framework Programme. The question central to this research is whether recent changes to consumer and commercial practices developed…

In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.

Protonentherapie is een nieuwe manier om kanker te behandelen waarbij de bestralingsdoses preciezer worden afgegeven. Dit zorgt voor minder schade aan omliggend weefsel en minder bijwerkingen. Prof. dr. Marco van Vulpen is medisch directeur van HollandPTC in Delft waar wordt onderzocht wat de maatschappelijke…

This dissertation is about Bayesian learning from data. How can humans and computers learn from data?

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Bij sommige jongeren met suïcidale gedachten en gedragingen is er een subtiel maar significant verschil in de hersenstructuur, zo blijkt uit onderzoek. 'Het resultaat vertelt wellicht meer over de mechanismen bij suïcidaal gedrag in een specifieke subgroep', zeggen postdoctoraal onderzoeker Laura van…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Promotores: H.W. Lenstra, A. Lucchini