Promotor: Prof.dr. L.J. Slikkerveer

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

In times of hardships or crisis, local people know how to deal with it using their resourcefulness. Although efforts are sometimes made by the government to help them, they are fully aware that community support is at least equally important.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

Maandelijks interviewen we een student of medewerker van de Universiteit Leiden over hun werk of studie in relatie tot duurzaamheid.

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Lezing

This dissertation investigates how the efficiency of Computed Tomography (CT) can be improved for dynamic scientific and industrial applications.

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

Op 21 januari 2020 verdedigde Patrick van Berlo zijn proefschrift 'Human Rights Elephants in an Era of Globalisation: Commodification, Crimmigration, and Human Rights in Confinement'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.P. van der Leun en prof.mr.dr. M.A.H. van der Woude.

The path to rational drug and dose selection

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Ontdek het studieprogramma van de éénjarige MSc Nederlandse Politiek aan Universiteit Leiden: kernvak, keuzevakken, onderzoeksvaardigheden, scriptiebegeleiding en stageoptie.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Maak kennis met de wetenschap via deze activiteiten bij de universiteit of op school.

In 2016 hebben Universitaire Medische Centra (UMC's) van Nederland de zelfevaluatie-tool ontwikkeld gebaseerd op het PhD Competence Model. Onze partners van de Universiteit Utrecht stellen een digitale versie van de tool kosteloos beschikbaar voor onze promovendi binnen de Universiteit Leiden, ook voor…

Binnen de Faculteit der Wiskunde en Natuurwetenschappen zijn 8 instituten:

Acht op de tien experimentele geneesmiddelen overleven de testfase op patiënten niet. Piet Hein van der Graaf, hoogleraar Systeemfarmacologie, wil die verspilling van tijd en geld voorkomen met nieuwe meet- en rekenmethoden.

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…

Onderzoek in het BioTherapeutics onderzoeksprogramma is gericht op een soepelere en snellere transitie van preklinisch onderzoek naar geneesmiddelen en op het afleveren van medicijnen in het menselijk lichaam met behulp van kleine moleculen en ‘biologics’.

Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia

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This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Risk has become one of the defining features of modern society. This course examines various types of safety and security risks, and how these are perceived and dealt with in a wide array of professional and academic fields, ranging from criminology, counter-terrorism and cyber security, to philosophy,…

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements

Quantum annealing belongs to a family of quantum optimization algorithms designed to solve combinatorial optimization problems using programmable quantum hardware. In this thesis, various methods are developed and tested to understand how to formulate combinatorial optimization problems for quantum…

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk

Onder de gezamenlijke titel ‘Scarcity and the State’ verschenen onlangs twee Engelstalige boeken over de verdeling van schaarse publieke rechten (Intersentia 2016). Paul Adriaanse (UL), Frank van Ommeren (VU), Willemien den Ouden (UL) en Johan Wolswinkel (Tilburg University) voerden de redactie. Aan…

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

The main aim of this project is to reveal and unravel the invisible histories of the UN, transcending the dominant Western perspective to recover the historical agency of Global South actors. The research will investigate how the UN has both facilitated and limited their role in shaping global order…