Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Lezing

De Internationale Astronomische Unie (IAU) krijgt een nieuwe president. Vanaf 2018 zal Ewine van Dishoeck, hoogleraar moleculaire astrofysica in Leiden en de meest geciteerde moleculair astrofysicus ter wereld, de leiding hebben over deze prestigieuze vakorganisatie, die astronomen wereldwijd vereni…

De Leidse astronoom Huib Jan van Langevelde is benoemd tot directeur van het Event Horizon Telescope (EHT)- consortium. De EHT is een project waarbinnen zo’n 350 wetenschappers uit 18 landen samenwerken. De EHT bundelt de grote ALMA-telescoop in Chili met andere (sub)millimetertelescopen en publiceerde…

Nieuwe krachtige telescopen, zoals de European Extremely Large Telescope, zullen de atmosferen van aardachtige planeten gaan ontrafelen met behulp van nieuwe waarneemmethoden zoals onder ontwikkeling in Leiden. Zuurstof kan dan mogelijk als eerste bewijs dienen voor buitenaards leven.

Het doel van het MODOMA-project is om een computermodel van taalverwerving te maken.

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

Quantitative biology means exploiting mathematical modelling and computer simulation as a tool to gain additional insights into the meaning of experimental data. Discover in this minor when and how to apply these tools, in a multidisciplinary setting.

Als mensen met elkaar praten wisselen sprekers elkaar soepel af, met gemiddeld zeer korte tussenliggende pauzes. Gesprekspartners moeten daarom steeds vooruit plannen wat ze willen zeggen en wanneer ze de beurt kunnen overnemen. Spraakmelodie speelt hier hoogstwaarschijnlijk een rol bij, maar onduidelijk…

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

The thesis describes experimental steps towards reduction of friction on the macroscopic scale by scenarios of thermo- and superlubricity well-known on the nanoscale.

Röntgendiagnostiek is vooral bekend uit de medische techniek. Maar ook in de sterrenkunde speelt röntgenstraling een belangrijke rol. Jelle Kaastra, hoogleraar Hoge energie astrofysica, is gespecialiseerd in het onderzoek aan de röntgenstraling van actieve melkwegstelsels en clusters van melkwegstel…

Een maansteen van de Apollo 17-missie, antieke globes en de kosmos volgens Wassily Kandinsky. Ewine van Dishoeck, hoogleraar Moleculaire astrofysica, stelde een indrukwekkende expositie samen in Rijksmuseum Boerhaave.

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Mechanical interactions between cells and their environment play an important role in many biological processes.

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

Hot rocky exoplanets are planets that orbit so close to their host star that they possess a molten surface.

SHINE-VR is een korte interventie in Virtual Reality (VR) die wordt toegevoegd aan een reguliere traumabehandeling (TF-CBT). We onderzoeken de effectiviteit ervan met een experimenteel ontwerp waarbij naar individuele gevallen wordt gekeken. Dit doen we specifiek met jongvolwassenen die seksueel misbruik…

Promotie

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Triplet superconductivity refers to a condensate of equal-spin Cooper pairs (pairs of electrons with equal spin).

Promotor: M. Ubbink, Co-promotor: G. Siegal

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

Het project onderzoekt hoe tweetalige sprekers omgaan met lexico-syntactische kenmerken – waaronder grammaticaal geslacht, classifiersystemen en de lineaire volgorde van adjectieven en naamwoorden – in het Spaans en het Chinees, zowel in eentalige als tweetalige contexten.

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

This thesis combines field and laboratory studies to address some of the most pressing questions in the field of microplastic research.

Promotor: A.P.IJzerman Co-promotor: A. Bender

This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

Humans share meaning through language. Over time, repeated interactions have shaped languages into forms that match our cognitive preferences, making them structured, expressive, easy to learn, and ultimately, meaningful.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Dit doctoraatsproject onderzoekt voornamelijk op welke manier (d.w.z. serieel, parallel of op een andere manier) de parser het Mandarijn-Chinees verwerkt. Daarnaast wordt onderzocht of er specifieke taalkundige kenmerken zijn die de decodering van het Mandarijn-Chinees bepalen en die verschillen van…

Over geschiedenis van de sterrenkunde van radioastronomie tot exoplaneten, de revolutionaire ontwikkeling van de naoorlogse sterrenkunde.

This thesis investigates the evolution and fate of gaseous exoplanets, which are continuously shaped by stellar activity across both short and long timescales.

Forming at the nodes of the Cosmic Web and growing hierarchically via mass accretion, galaxy clusters are the largest virialized halos in our universe, composed of dark matter (DM; ≥85%), ionized hot plasma in the intracluster medium (ICM; ≥10-15%), and galaxies (≥1-5%).

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…