This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Kunnen suikerpatronen op cellen het immuunsysteem activeren om kanker te bestrijden? Sander van Kasteren gebruikt de beurs van de European Research Council (ERC) om te ontdekken of dit mogelijk is.

De bedrijfsDocent Ontwikkel Teams voor natuurkunde, scheikunde en wiskunde zijn in maart succesvol van start gegaan. In de bijeenkomsten, waar professionals uit het onderwijs onder leiding van een deskundige samenkomen, kunnen de docenten werken aan hun eigen ontwikkeling als docent en aan de ontwikkeling…

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

Promotor: Prof.dr. M. Ubbink

The International Course on Water Use and Management in Cagayan Valley The Philippines (2011-2015)

This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Promotor: F.J. van Lunteren, E. Jorin

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Ruim 3500 enthousiaste Leidse eerstejaars, waarvan 80% universitair, verzamelen zich op maandagochtend 13 augustus voor het eerst op de Lammermarkt bij de start van de EL CID. Bij een stevige beat vormen de groepjes zich in twee shifts, om 9.30 u en om 11.00 u, rond hun mentoren.

Een internationaal team astronomen, onder leiding van sterrenkundigen werkzaam aan de universiteiten van Amsterdam, Leiden en Hawaii, mag als een van de eerste in de wereld gaan meten met de James Webb Space Telescoop. Met hun project 'Ice Age' gaan ze ijzige stofdeeltjes in de ruimte onderzoeken.

Op 1 februari 2016 is bij het Nederlands Instituut in Marokko (NIMAR) het Rabat-semester voor de nieuwe lichting studenten Arabisch (Midden-Oostenstudies) van start gegaan. Tijdens dit semester gaan studenten intensief aan de slag met Modern Standaard Arabisch, Marokkaans Arabisch en Berbertalen en…

Voor iedereen die interesse heeft in ondernemen en startups, is woensdag 25 november een belangrijke datum. Dan vindt het evenement ‘Leiden Start!’ plaats, een informatiemarkt en netwerkgelegenheid voor onder meer (aspirant) ondernemers, investeerders en coaches.

Vandaag start in Leiden de nieuwbouw van studentencomplex Kolffpad met 289 woningen voor studenten van de Universiteit Leiden. Eigenaar is Stichting DUWO, de locatie in het Bioscience park is van de universiteit. Medio 2023 moet het gebouw klaar zijn.

Met het inzaaien van het laatste proefveldje ging op 29 juni het nieuwe onderzoeksplatform TERRA-Dunes officieel van start. Het experiment heeft een fundamenteel wetenschappelijk karakter, maar heeft belangrijke toepassingen in bijvoorbeeld herstel van natuurkwaliteit.

How were the Russians, under early modern conditions, able to incorporate this distant, undeveloped and, because frequent nomadic attacks, dangerous territory? And what role did the Kolyvan-Voskresensk plants play in this process?

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Promotor: E.F. Smets, Co-promotor: J. Geml

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

In this thesis, we present new laboratory data of interstellar dust analogues.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou