The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

In dit project worden reisverslagen over Nederlands-Indië bestudeerd die zijn geschreven tussen 1800 en het einde van de Tweede Wereldoorlog. Door zowel Nederlandse reisteksten als inheemse reisteksten in het Javaans en Maleis te analyseren, wordt een nieuw, tweestemmig perspectief op (de geschiedschrijving…

Een twintigtal Nederlandse politicologen buigt zich over de oorzaken, gevolgen en vooruitzichten van het algemeen kiesrecht in Nederland. Liep Nederland voorop of juist achteraan bij de invoering van kiesrecht voor mannen en iets later voor vrouwen? Hoe hebben burgers de afgelopen eeuw gebruik gemaakt…

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

The overall theme of this thesis is to complement the electrochemical data acquired in fuel cell research with in situ X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS).

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

Promotie

Onderzoeken en ontwerpen zijn twee vaardigheden die steeds belangrijker worden in de vakken O&O (onderzoeken en ontwerpen) en NLT (natuur, leven en technologie). Uit onderzoek van Tessa Vossen (ICLON en Faculteit Wiskunde en Natuurwetenschappen) blijkt dat docenten en leerlingen de relevantie van onderzoeken…

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Details kunnen zien van een zieke of gezonde cel, dat is mogelijk met de supermicroscoop van het consortium Cyttron. Niet alleen de microscoop is vernieuwend in zijn soort: ook de vorm waarop de partijen samenwerken past in de huidige tijd. “Toegang tot elkaars techniek, daar draait het om in ons samenwerkingsverband”,…

Met de nodige maatregelen starten onderzoekers hun werkzaamheden in verschillende laboratoria weer deels op. Het Leidse Cell Observatory is één van de plekken waar wetenschappers sinds 11 mei hun labwerk hervatten.

Promotor: Prof.dr. T. Schmidt

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotor: Prof.dr. G.P. van Wezel

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

Promotor: Prof.dr. J. Kuiper

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Criminologe Marieke Liem is genomineerd voor de verkiezing New Scientist Wetenschapstalent 2015. Stemmen kan tot maandag 7 september.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Promotor: Prof.dr. R.M.H. Merks

Het wemelt van de peilingen in de aanloop naar het Britse referendum op 23 juni. Politicoloog Tom Louwerse over de zin en onzin daarvan. ‘Het is vooral belangrijk hoe de media een partij framen op basis van de polls.’

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

De tussentijdse verkiezingen in de Verenigde Staten worden een motie van goed- of afkeuring over president Donald Trump en zijn politiek van verdeeldheid, zegt Brendan Carroll, universitair docent Bestuurskunde. In dit blog legt hij uit waarom de opkomst wellicht een beslissende factor wordt.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

In november zijn er Tweede Kamerverkiezingen, maar niet iedereen gaat stemmen. Hoe komt dat, en hoe erg is dat? Internationaal onderzoek naar opkomstpercentages bij verkiezingen werpt nieuw licht op deze vraag – en biedt alternatieven.

Stem voor de Ontdekker van het jaar 2017! Wie van deze onderzoekers verdient volgens jou een prijs voor zijn of haar werk? Vanaf nu kan je stemmen!

Scott Waitukaitus is namens LION genomineerd als Discoverer of the Year 2017. Breng snel je stem uit!

This dissertation combines the use of defined microenvironments, high-resolution fluorescence microscopy, and time-resolved analysis, to study intracellular and cellular motility.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Het verhaal van Rosalin Kuiper kent vele vertakkingen, en ze komen allemaal uit op zee. Als studente Psychologie koos Rosalin voor een leven als profzeiler.