Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Vanaf de koloniale tijd tot heden hebben grote aantallen Javanen hun woonplaats verlaten om zich in andere delen van Indonesië of veel verder weg te vestigen. Vaak was deze spreiding gedwongen, vaak met traumatische gevolgen.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

This dissertation presents new cryptographic protocols, which can be divided into two families.

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.

In dit artikel onderzoeken Thijs van Dooremalen en Philip Smith hoe het publieke discours over hittegolven is verschoven in Britse kranten.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

Dit project bekijkt het Oudgrieks vanuit het perspectief van de alledaagse schrijvers. Een corpus van meer dan 60.000 Griekse teksten op papyrus, van privébrieven tot petities en contracten geeft ons toegang tot de Griekse taal zoals die werd geschreven door gewone mensen in de oudheid (van 300 v.Chr.…

Dit deelproject pleit voor een nauwkeurige en forensische reconstructie van de financiële stromen van en naar de Sovjetrepublieken in Centraal-Azië in de naoorlogse periode.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Lezing, Research Seminar

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

The global agri-food system plays a critical role in food security and environmental issues.

Irene Khan, expert op het gebied van mensenrechten, werpt een aantal vragen op: Wat kan men verstaan onder een ‘Culture of Justice’? Wie bepaalt wat 'Justice' is? Hoe realistisch is de bevordering van ‘Rule of Law’ en ‘Justice’ in landen waar sprake is van ernstige conflictsituaties en armoede?

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Leiden is een echte studentenstad. Meld je aan voor een studievereniging of studentenvereniging om van jouw studietijd een onvergetelijke tijd te maken!

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

Onder welke omstandigheden beperken paramilitaire groepen hun gebruik van politiek geweld? Dit artikel onderzoekt het gebruik hiervan door de PIRA.

Dit artikel gaat in op de onderzoekskloof door te onderzoeken hoe deze instanties hun personeel zo kunnen inzetten dat ze maximale prestaties leveren met het personeel dat ze hebben.

Lezing, Global Histories of Knowledge Seminar

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Dit artikel levert een bijdrage aan een groeiend aantal onderzoeken naar radicalisering. Het richt zich specifiek op het onderscheid tussen individuen die radicalisering en daardoor betrokken raken bij terroristisch geweld en individuen die radicaliseren maar niet betrokken raken bij geweld.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

De auteurs onderzoeken de afhandeling van cybermisdaadzaken door rechtshandhavers.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Om de klimaatcrisis het hoofd te bieden, kan een bepaalde nederigheid van de mens ten aanzien van de natuur van groot belang zijn. Tegelijkertijd kan nederigheid ook politieke overheersing in de hand werken. Hoe kunnen mensen zich op een bescheidener manier tot de natuur verhouden zonder hun vrijheid…

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.