This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Eva Michaels & Monika Sus onderzoeken strategische autonomie in EU-buitenlands beleid, de evolutie wordt gevolgd van Saint-Malo Verklaring tot de huidige focus.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

CrO2, a half-metal ferromagnet, has shown great promise for superconducting spintronics applications for nearly two decades.

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

Een goede taalontwikkeling is van belang voor de cognitieve en sociale ontwikkeling, om te kunnen communiceren en om te kunnen leren. Als de taalontwikkeling niet verloopt zoals verwacht, kan dit allerlei consequenties hebben. Kinderen met een extra X of Y chromosoom hebben een verhoogd risico op problemen…

We are living in an information era where the amount of image and video data increases exponentially.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Promotie

Promotie

Promotores: R. Tijdeman, K.J. Batenburg

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Promotor: J. Aarts

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

Op 19 september 2019 verdedigde Lynette Janssen zijn proefschrift 'EU Bank Resolution Framework: A comparative study on the relation with national private law'. Het promotieonderzoek is begeleid door promotoren prof.mr. W.A.K. Rank en prof.mr. M. Haentjens.

In dit artikel onderzoeken Malte Reimann en Antonio Cerella hoe politiek en geneeskunde nauw met elkaar verweven zijn geraakt. Ze gebruiken daarbij het gedachtegoed van Roberto Esposito om deze relatie opnieuw te bekijken vanuit het perspectief van een bevestigend biopolitiek.

Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

Dit artikel beschrijft het ontstaan van een app die kan helpen om het klimaatbewustzijn en de actie wereldwijd te vergroten.

This paper presents the prevalence and characteristics of firearm homicides in Denmark, Finland, the Netherlands, Sweden and Switzerland

Dit artikel onderzoekt aanmoediging door leiderschap en psychologische veiligheid als antecedenten van prosociaal regelovertredend gedrag (PSRB).

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

Details kunnen zien van een zieke of gezonde cel, dat is mogelijk met de supermicroscoop van het consortium Cyttron. Niet alleen de microscoop is vernieuwend in zijn soort: ook de vorm waarop de partijen samenwerken past in de huidige tijd. “Toegang tot elkaars techniek, daar draait het om in ons samenwerkingsverband”,…

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Met de nodige maatregelen starten onderzoekers hun werkzaamheden in verschillende laboratoria weer deels op. Het Leidse Cell Observatory is één van de plekken waar wetenschappers sinds 11 mei hun labwerk hervatten.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Promotor: Prof.dr. T. Schmidt

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

In this project, researchers from computer science, law, psychology, and public administration research in practice how artificial intelligence (AI) can be leveraged to make decision-making in the security domain more effective, while also keeping it safe and accountable.

Op 21 oktober 2021 verdedigde Frederik Behre het proefschrift 'A European Ministry of Finance?'. Het promotieonderzoek is begeleid door promotor prof.dr. S.C.G. Van den Bogaert.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

This thesis introduces a relational interaction model and a practical tool for describing, visualising and generating interactive dialogues.