This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Supervisor: P.J.J. Hooykaas

This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

Promotie

Onderzoekers hebben een materiaal ontwikkeld dat ingaat tegen een van de basisprincipes van de natuurkunde. Reguliere materialen die ingedrukt worden, verspreiden de druk gelijkmatig, ongeacht waar die vandaan komt. Het nieuwe materiaal breekt met deze wetmatigheid en dat kan interessant zijn voor toepassingen…

Promotor: Prof.dr. M. Ubbink

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Zeven nieuwe Medical Delta-hoogleraren ontvouwen hun onderzoeksplannen in een oratiemarathon op 21 juni. De hoogleraren van de Universiteit Leiden, het LUMC, de TU Delft en het Erasmus MC Rotterdam opereren op het snijvlak van de life sciences en gezondheid en technologie.

This research project studies the distribution and impact of medieval malaria in the Netherlands.

Neurolaw is een relatief jonge discipline, waarin de impact van de neurowetenschappen op het recht, de juridische praktijk en de criminologie wordt onderzocht. De actuele ontwikkelingen binnen de neurowetenschappen (neurobiologie, -psychologie en -psychiatrie) hebben de betekenis van onderzoek op dit…

De publicatie van de groep Catherijne Knibbe werd in 2016 bekroond met de AAPS Pharmaceutical Research Meritorious Manuscript Award.

Promotie