651 zoekresultaten voor “discover of the year” in de Publieke website
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Uitnodiging Jaap Doek Kinderrechtenscriptieprijs 2016 & Boekpresentatie ‘25 years CRC’
De Afdeling Jeugdrecht en Defence for Children nodigen u van harte uit voor de uitreiking van de vierde Jaap Doek Kinderrechtenscriptieprijs en de officiële presentatie van het boek ‘The United Nations Convention on the Rights of the Child. Taking Stock after 25 Years and Looking Ahead’.
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Another Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Astrophysical plasma modeling of the hot Universe: Advances and challenges in high-resolution X-ray spectroscopy
Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.
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Establishment of the European Stability Mechanism for the Eurozone
In dit artikel onderzoeken Madeleine O. Hosli en Wen Pan hoe intergouvernementele dynamieken het Europees Stabiliteitsmechanisme vormgaven, waarbij ze Liberale Intergouvernementalisme gebruiken om onderhandelingsfasen, de invloed van grote lidstaten en de geldigheid van theoretische aannames te anal…
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Biomimetic redox reactions of the Cu(II) μ-thiolate complex
Promotor: Prof.dr. E. Bouwman
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The Transformation of the Euro: Law, Contract, Solidarity
Op 31 januari 2018 verdedigde Vestert Borger zijn proefschrift getiteld ‘The Transformation of the Euro: Law, Contract, Solidarity’. Het promotieonderzoek is begeleid door professor Stefaan Van den Bogaert (promotor) en dr. Jorrit Rijpma (co-promotor).
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New dimensions of the cellular response to DNA damage
Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.
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Galaxy formation and the structure of the Universe
Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)
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Amoeboid cell migration and physicochemical properties of the extracellular environment
This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…
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Judicial transformation: The case of the Polish Constitutional Tribunal
In dit artikel onderzoeken Jaroslaw Kantorowicz en zijn coauteurs hoe recente politieke veranderingen het Poolse Grondwettelijk Tribunaal hebben hervormd en waarom deze ontwikkeling belangrijke inzichten biedt in hedendaagse democratische achteruitgang in Europa.
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Pensions, Retirement, and the Financial Position of the Elderly
Langetermijnontwikkelingen, zoals het verouderen van de bevolking, de toename in de gemiddelde levensverwachting en de gevolgen van de recente financiële crisis, hebben bijgedragen aan de discussie rondom de houdbaarheid van het pensioenstelsel.
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Implementation of the EU Preventive Restructuring Directive Part I
In 2019 hebben het Europees Parlement en de Raad de Richtlijn Preventieve Herstructurering (2019/1023) aangenomen, die voorziet in minimale harmonisatie van onder andere preventieve herstructureringskaders (preventive restructuring frameworks, 'PRF'). Dit boek biedt verdiepende analyses van de implementatie…
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Activity-based proteomics of the endocannabinoid system
This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.
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Transboundary Crisis Management Capacities of the European Union
Dit project onderzoekt het coördinerend vermogen van de EU in ernstige crises.
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Estimation and Optimization of the Performance of Polyhedral Process Networks
Promotor: Prof.dr.ir. E. Deprettere
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Andeweg, Irwin & Louwerse, Governance and Politics of the Netherlands
Al jaren hét standaardwerk over politiek en openbaar bestuur in Nederland. Volledig, diepgaand en up-to-date.
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Historical institutionalism and policy coordination: origins of the European semester
This paper explores whether multilateral surveillance and policy coordination under the ES was based on a path-changing or a path-dependent mechanism
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The pre-Roman elements of the Sardinian lexicon
Op 12 februari promoveert Cid Swanenvleugel. Het Leiden University Centre for Linguistics feliciteert Cid!
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Explaining Contestation: Votes in the Council of the European Union
The researchers examine the Council of the European Union's voting behaviour between 2010 and 2021 and the impact of different independent variables.
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Play by the rules? : coordination of EU sustainable development policies and the importance of the politico-legal context
There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…
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Iber Kasehatan in Sukamiskin: Utilisation of the Plural Health Information and Communication System in the Sunda Region of West Java, Indonesia
This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.
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Ecology of the Ethiopian wolf (Canis simensis Rüppell 1835) in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of
Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.
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Breaking the witches' spell: towards steering the soil microbiome for volatile-mediated control of the root parasitic weed Striga
Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.
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A search for transient reductions in the speed of sound of the inflaton in cosmological data, and other topics
Promotor: Prof.dr. A. Achucarro
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Studieprogramma
Ontdek het studieprogramma van de éénjarige MSc Nederlandse Politiek aan Universiteit Leiden: kernvak, keuzevakken, onderzoeksvaardigheden, scriptiebegeleiding en stageoptie.
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink
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Studies and Western Esotericism (University of Amsterdam), Academic Year 2023–2024
Religious Studies at the University of Amsterdam organises a postgraduate seminar on current issues in religious studies and western esotericism. You can find the programme for the year 2023-2024 below.
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and planning of Amazigh languages in Morocco: a study of the language ideology of the Royal Institute of Amazigh Culture (IRCAM)
Op 6 januari promoveert Kefan Bao. Het Leiden University Centre for Linguistics feliciteert Kefan!
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CfP: Annual Conference of the International Society for the Study of Medieval Theology
On June 26-28, 2024, the Annual Conference of the International Society for the Study of Medieval Theology will take place. The theme this year is "The End: Finiteness, Death and Completion in Medieval Theology". Deadline for paper proposals: 20 December 2023.
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Economic value of non-timber forest products among Paser Indigenous People of East Kalimantan
Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh
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Boeklancering 'The United Nations Convention on the Rights of the Child’
Het boek 'The United Nations Convention on the Rights of the Child' is het resultaat van internationale wetenschappelijke congres - '25 Years CRC' – dat plaatsvond in november 2014 in Leiden ter gelegenheid van de 25e verjaardag van het VN-Kinderrechtenverdrag.
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Lokal: indigenous medical knowledge and practice for integrated nursing of the elderly with cardiovascular disease in Sumedang, West Java: towards
The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.
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Symposium: The digital reconstruction of the crucifixion of the Lindau master
On 8 July, the symposium 'The digital reconstruction of the crucifixion of the Lindau master (ca. 1425)' will take place at the auditorium of Museum Catharijnecovent, from where it will also be broadcasted online.
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Influence of the electrode-electrolyte interface on electrochemical CO2 reduction reaction and hydrogen evolution reaction
The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.
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Permanent change? the paths of change of the European security organizations
Betekenen recente ontwikkelingen in de Europese veiligheidsarchitectuur het einde van de multilaterale samenwerking, of juist het begin van een nieuw tijdperk?
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Validity in teacher assessment. An exploration of the judgement processes of assessors
In dit proefschrift staat validiteit in de beoordeling van docentcompetenties centraal.
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Diversity and Functional Potential of the Sorghum Root Microbiome to Control Striga hermonthica
Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…
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The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal
Op 16 december 2019 verdedigde Jan-Harm de Villiers zijn proefschrift 'The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal'. Het promotieonderzoek is begeleid door promotor prof.dr. P. Cliteur.
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Van Ham, Thomassen, Aarts & Andeweg (eds), Myth and Reality of the Legitimacy Crisis
Beleeft de democratie daadwerkelijk een legitimiteitscrisis? De auteurs toetsen de stelling dat gevestigde democratieën aan legitimiteit inboeten. Voorts bekijken zij in hoeverre bestaande theorieën de legitimiteitscrisis zien en verklaren. Ook onderzoeken zij nieuwe mogelijkheden voor het bestuderen…
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Patient-derived models of breast cancer: a breakthrough story of the duct
To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…
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Spontaneous hospitalization in the immediate aftermath of the Manchester arena bombing
In dit artikel presenteren Andrea Bartolucci en Michele Magni een evidence-based onderzoek naar de spontane opname van slachtoffers en de verdeling van patiënten in de onmiddellijke nasleep van de Manchester Arena Bombing.
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Effects of the early social environment on song and preference learning in zebra finches
Songbirds as vocal learners learn their songs and song preference from social tutors. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song.
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On the origin of ‘bloopergenes’: unraveling the evolution of the balanced lethal system in Triturus newts
This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Guidance documents of the European Commission in the Dutch legal order
Op 11 februari 2020 verdedigde Clara van Dam haar proefschrift 'Guidance documents of the European Commission in the Dutch legal order'. Het promotieonderzoek is begeleid door promotoren prof.dr. W. den Ouden en prof.dr. J.E. van den Brink (UvA).