The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Promotor: Prof.dr. J. Kuiper

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Supervisor: P.J.J. Hooykaas

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

Lipid nanoparticles (LNPs) have enabled the success of mRNA vaccines but remain limited in broader therapeutic use by challenges in delivery efficiency, targeting, and mechanistic understanding.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

This book explores the spiritual potential of faith, mysticism and transcendence in answer to the dangers of a mythologised state and the sacro-sanctification of (liberal) democracy and its rule of law.

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Understanding interactions in quantum many-body systems remains one of the most profound and difficult challenges in condensed matter physics.

Promotores: Prof. dr. G.R. (Geert) de Snoo, Dr. E. (Ester) van der Voet

Promotor: K.J. Batenburg

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

In the first part of this thesis we study the geometry of folding patterns.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

In Nederland bieden ongeveer 130 van de 700 middelbare scholen een tweetalige stroom aan. Toch is er nog maar weinig wetenschappelijk onderzoek naar CLIL (content and language integrated learning). Met haar proefschrift wil Evelyn van Kampen (promovendus bij het ICLON) bijdragen aan een beter begrip…

This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

Promotor: S.M. Verduyn Lunel

In september 2017 start de nieuwe Engelstalige bacheloropleiding Security Studies in Den Haag. Het onderwijsprogramma is ontwikkeld door het Institute of Security and Global Affairs (ISGA) van de Universiteit Leiden. De opleiding beantwoordt aan de grote behoefte aan breed opgeleide academici in het…

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

Promotor: Prof.dr. M. Ubbink

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Waarom is het leren van een tweede of vreemde taal zoveel moeilijker dan het leren van je moedertaal? En in hoeverre is het hebben van een ‘talenknobbel’ van belang? Wat is het belang van onderwijs en motivatie? Neem kennis van theoretisch en experimenteel onderzoek en onderzoek zelf een taalonderwijspraktijk…

Promotor: Prof.dr. G.J. Kroes

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Technologies that help to enhance our educational environments can be found everywhere.

Het Leiden University Centre for Linguistics (LUCL) wil haar maatschappelijke relevantie aantonen door middel van hoogwaardig onderzoek, excellent onderwijs en diverse outreachende activiteiten. Een paar hoogtepunten:

The thesis is part of a bigger project, the HEPGAME (High Energy Physics Game). The main objective for HEPGAME is the utilization of AI solutions, particularly by using MCTS for simplification of HEP calculations.

The ultimate aim of this project is to improve cooperation between courts in different Member States.

Promotie

Op 6 januari promoveert Kefan Bao. Het Leiden University Centre for Linguistics feliciteert Kefan!

Leiden University would like to express its concern about the proposed Hungarian higher education draft law, which, if adopted, would make the functioning of Central European University (CEU) in Budapest nearly impossible. These changes would endanger the academic freedom vital for CEU’s continued operation…