This thesis describes how to scale down concepts of macroscopic mechanical metamaterials to the thermal scale using a system of flexibly-linked colloids.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

In my research, I used a comparative wood anatomical approach to address wood evolution of the (largely) tropical flowering plant families Apocynaceae and Sapotaceae.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

This dissertation, Layered Loyalties: The Natuurkundige Commissie in the Netherlands Indies (1820-1850), studies the Natuurkundige Commissie.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

In this dissertation (titled: Exploring the Synergies between Transfer in Reinforcement Learning and Procedural Content Generation) we explore how the two research fields named in the title, namely Transfer in Reinforcement Learning (TRL) and Procedural Content Generation (PCG) can synergize togethe…

De Leidse chemicus Dennis Hetterscheid krijgt een ERC Starting Grant voor onderzoek naar de omzetting van zonlicht in duurzame en op grote schaal transporteerbare energie. Hij wil dit bewerkstelliggen met op de natuur geïnspireerde katalysatoren.

Met de nodige maatregelen starten onderzoekers hun werkzaamheden in verschillende laboratoria weer deels op. Het Leidse Cell Observatory is één van de plekken waar wetenschappers sinds 11 mei hun labwerk hervatten.

In september start de Leergang Arbeidsrecht! Al jaren een prachtige cursus voor wie na enkele jaren praktijkervaring haar of zijn kennis wil verbreden en verdiepen. We zijn trots op het vernieuwde programma en op het docententeam met vele toppers uit praktijk en wetenschap.

In januari starten negentien MOOCs van de Universiteit Leiden. Iedereen kan gratis deelnemen aan deze online cursussen, die variëren van terrorismebestrijding tot niertransplantatie.

Het huidige systeem van accreditatie en visitatie van onderwijs en opleidingen voldoet niet. Dat blijkt uit Leids wetenschappelijk onderzoek naar de laatste onderwijs-accreditatieronde. De bureaucratische last is te groot en verbetering van de onderwijskwaliteit wordt er onvoldoende mee bereikt. Daarom…

Onze cursussen september beginnen binnenkort, zorg dat u op tijd bent met uw aanmelding

MOOC Music & Society

Promotor: Prof.dr. M.A.G.J. Orrit

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The upscaling of Life Cycle Assessment (LCA) data is recognized as one of the main challenges in the ex-ante LCA of emerging technologies. This challenge arises since industrial-scale system specifications for these technologies are unknown and industrial data is lacking.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Promotor: Prof.dr. G.R. de Snoo

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Kledingontwerper, manager bij een multinational of dermatoloog: de twintig vluchtelingstudenten die deelnemen aan het Voorbereidend Jaar Leiden (VJL) bruisen van ambitie. Op donderdag 26 januari ging het studiejaar feestelijk van start.

Zeven wetenschappers van de Universiteit Leiden krijgen een ERC Starting Grant. Met deze subsidie kunnen onderzoekers hun eigen project lanceren, een eigen onderzoeksteam vormen en hun beste ideeën uitvoeren.